Effectiveness of Bokeria-Boldyrev ACH Solution in Surgerical Treatment of Adult Patients with Obstructive Hypertrophic Cardiomyopathy.

The study examined effectiveness of pharmaco-cold cardioplegia employing solutions of enhanced buffer capacity during surgery of obstructive hypertrophic cardiomyopathy in adult patients (N=51) operated during 2013-2018. In group 1 (N=28), the cardioplegia was performed with HTK (Custodiol) solution, whereas in group 2 (N=23), it was carried out with Bokeria-Boldyrev ACH solution. The mean, minimum, and maximum ages in group 1 were 46, 21, and 64 years, respectively; in group 2 - 42, 14, and 70 years, respectively.

Experimental study of the effects of sodium ion concentrations on the function of the myocardium exposed to cardioplegic ischemia.

A new cardioplegic solution based on three natural dipeptides was developed and introduced at the Laboratory of Cardioplegia, A. N. Bakulev Research Center of Cardiovascular Surgery.

Bioelectric impedancemetry of the myocardium during cardiac surgery with artificial circulation.

We analyzed changes in bioelectric impedance of the myocardium during cardiac surgery under conditions of cardioplegy. The results suggest the possibility of using bioelectric impedancemetry for evaluation of the state of the myocardium during surgery. Bioelectric impedancemetry allows evaluation of interstitium filling during infusion of the cardioplegic solution and reperfusion damage to cardiomyocytes.

Feasibility of myocardial pH-monitoring during heart surgery under conditions of cardioplegic ischemia.

The first results of the use of pH-monitoring of the myocardium with a Khuri monitor (Terumo Cardiovascular Systems Corporation) are presented. Before aorta clamping, the pH changes depended on the initial degree of damage to the examined myocardial segment. The cardioplegia protocol was urgently modified due to pH-monitoring, which helped to normalize pH and to prevent severe postoperative complications.