Upper limb salvage with massive intercalary allograft for humeral chondrosarcoma.

Introduction: chondrosarcoma is a high-grade malignant tumor composed of mesenchymal cells with cartilage differentiation. It most frequently appears in the bones of the pelvis, the femur, and the humerus. The main management method is oncological resection with wide margins and function-preserving reconstruction.

A modular plasmid toolkit applied in marine bacteria reveals functional insights during bacteria-stimulated metamorphosis.

A conspicuous roadblock to studying marine bacteria for fundamental research and biotechnology is a lack of modular synthetic biology tools for their genetic manipulation. Here, we applied, and generated new parts for, a modular plasmid toolkit to study marine bacteria in the context of symbioses and host-microbe interactions. To demonstrate the utility of this plasmid system, we genetically manipulated the marine bacterium , which stimulates the metamorphosis of the model tubeworm, .

Hybrid prediction of infections and deaths due to COVID-19 in two Colombian data series.

The prediction of the number of infected and dead due to COVID-19 has challenged scientists and government bodies, prompting them to formulate public policies to control the virus' spread and public health emergency worldwide. In this sense, we propose a hybrid method that combines the SIRD mathematical model, whose parameters are estimated via Bayesian inference with a seasonal ARIMA model. Our approach considers that notifications of both, infections and deaths are realizations of a time series process, so that components such as non-stationarity, trend, autocorrelation and/or stochastic seasonal patterns, among others, must be taken into account in the fitting of any mathematical model.

A modular plasmid toolkit applied in marine Proteobacteria reveals functional insights during bacteria-stimulated metamorphosis.

A conspicuous roadblock to studying marine bacteria for fundamental research and biotechnology is a lack of modular synthetic biology tools for their genetic manipulation. Here, we applied, and generated new parts for, a modular plasmid toolkit to study marine bacteria in the context of symbioses and host-microbe interactions. To demonstrate the utility of this plasmid system, we genetically manipulated the marine bacterium , which stimulates the metamorphosis of the model tubeworm, .

Pandemic wave trends in COVID-19 cases, mobility reduction, and climate parameters in major metropolitan areas in the United States.

In this paper, we analyzed the association among trends in COVID-19 cases, climate, air quality, and mobility changes during the first and second waves of the pandemic in five major metropolitan counties in the United States: Maricopa in Arizona, Cook in Illinois, Los Angeles in California, Suffolk in Massachusetts, and New York County in New York. These areas represent a range of climate conditions, geographies, economies, and state-mandated social distancing restrictions. In the first wave of the pandemic, cases were correlated with humidity in Maricopa, and temperature in Maricopa and Los Angeles.