Publications by authors named "G A Beer"
Article Synopsis
- * The study examined the effects of tafamidis on tissue factor (TF) expression and activity in human aortic endothelial cells (HAECs), revealing that tafamidis significantly reduces TF levels when induced by inflammatory signals.
- * This reduction in TF activity suggests that tafamidis may help lower the risk of blood clots (thromboembolic complications) in patients with ATTR cardiomyopathy, providing insights into its potential benefits beyond just stabilizing TTR.
Article Synopsis
- X-linked hypophosphatemia (XLH) is a genetic condition caused by a mutation affecting the regulation of FGF23, which can lead to cardiovascular issues, but the extent of these effects in XLH patients is unclear.
- A study involving 13 pediatric XLH patients evaluated the impact of a 2-year treatment with burosumab, measuring various health metrics including cardiovascular health through blood pressure and echocardiograms.
- Results showed significant improvements in linear growth, a decrease in rates of overweight/obesity, and a reduction in elevated blood pressure, with no adverse cardiac effects noted during the treatment period.
Unlabelled: Both Neurofibromatosis type 1 (NF1) and Noonan syndrome (NS) are RASopathies. Characteristic cardiac phenotypes of NS, including specific electrocardiographic changes, pulmonary valve stenosis and hypertrophic cardiomyopathy have not been completely studied in NF1.
Purpose: The aims of this study were to assess: (1) similarities in the prevalence and types of ECG and conventional echocardiographic findings described in NS in asymptomatic patients with NF1, and (2) the presence of discrete myocardial dysfunction in NF1 patients using myocardial strain imaging.
Heart transplantation with donation after circulatory death (DCD) provides excellent patient outcomes and increases donor heart availability. However, unlike conventional grafts obtained through donation after brain death, DCD cardiac grafts are not only exposed to warm, unprotected ischemia, but also to a potentially damaging pre-ischemic phase after withdrawal of life-sustaining therapy (WLST). In this review, we aim to bring together knowledge about changes in cardiac energy metabolism and its regulation that occur in DCD donors during WLST, circulatory arrest, and following the onset of warm ischemia.
View Article and Find Full Text PDFIntroduction: The objective of this study was to investigate myocardial deformation of left (LV) and right ventricle (RV) using 2-dimensional speckle-tracking echocardiography (2D-STE) in fetuses with and without congenital cytomegalovirus (CMV) infection.
Methods: This was a prospective single-center study. Vertical transmission was defined by a positive CMV polymerase chain reaction (PCR) test on the amniotic fluid or on the neonate's urine.