Estimating aminoglycoside clearance and creatinine clearance in underweight patients.

Purpose: An adjustment factor (AF) was developed and evaluated to determine the best method for estimating aminoglycoside clearance (CL(amino)) and creatinine clearance (CL(cr)) in underweight patients.

Methods: This study was a retrospective, multicenter, chart analysis of aminoglycoside pharmacokinetic data obtained between January 2000 and August 2006 at the University of Southern California University Hospital and Cedars-Sinai Medical Center. Adult patients were included in this study if they had received inpatient aminoglycoside therapy, were at least 60 inches tall, and were at least 10% below their ideal body weight (IBW).

[Use of natural sorbents for isolating enteroviruses and hepatitis A virus from water samples].

The data of the study on optimal conditions for the use of a mineral sorbent, bentonite, for isolation of hepatitis A virus and enteroviruses from water bodies are presented.