[Erythrocytes of hetero- and homoiothermal animals in natural and artificial hypothermia].

By the low-angle light scattering technique there are revealed peculiarities of dynamics of transformation (osmotic fragility, level of hemolysis and ratio of forms by index of sphericity) of erythrocytes of hetero- (golden hamsters Mesocricetus auratus) and homoiothermal (white rats Rattus norbegicus) animals in natural hibernation and suspended animation, craniocerebral and immersion hypothermia. In control in hamsters the osmotic fragility and the level of hemolysis of erythrocytes were higher than in rats, predominant were modified forms (in particular stomatocytes). Under artificial hypothermia, regardless of the way of achievement, depth and duration, we observed changes similar in direction, but different in expression: the osmotic fragility and hemolysis increased, the portion of discocytes decreased (especially sharply in hamsters under suspended animation), the number of changed erythrocytic forms rose.

[Effect of different types of cold acclimation on osmotic fragility and sphericity index of rat erythrocytes].

The effect of different types of cold exposures, long-term and rhythmically organized (RCE), which increased organism adaptive ability to cold, on osmotic fragility and sphericity index of rat erythrocytes were studied. It is shown that depending on the type, intensity and duration of cold exposure the change of sphericity index occurred. More over, RCE1 (exposure temperature -12 °C, during 2 days) led to the increase in osmotic fragility, but RCE2 (exposure temperature 10 °C, during 2 days), RCE3 (exposure temperature 10 °C, during 1 month) and long-term (exposure temperature 5 °C, during 1 month) - to membrane modification without change in its osmotic fragility.

[Effect of hypothermia on reuptake of neuromediators by synaptosomes].

Cranio-cerebral hypothermia (temperature of the body 32-30 degrees C, of the brain 29-27 degrees C) was studied for its effect on the reuptake of neuromediators (3H-noradrenaline and [14C]GABA) by the cortex and hypothalamus synaptosomes of the rat brain. It was found that the reuptake of [3H]noradrenaline by the cortex synaptosomes under narcosis and cranio-cerebral hypothermia was inhibited much stronger than that by the hypothalamus synaptosomes. At the same time GABA-ergic synapses of the cortex and hypothalamus were not sensitive to narcosis.