[Effect of anti-angina therapy on phospholipid levels of the myocardium in ischemic lesions].

Antianginal treatment of animals with experimentally induced myocardial ischemia produced significant effects on the quantitative and qualitative composition of phospholipids: total phospholipids returned to normal levels, cardiolipins and phosphatidilinosytes were drastically increased. In ischemia, this lipid metabolism derangement appears to be of great significance as it enables the physiochemical status of biological membranes to be relatively stabilized, which is an essential condition for the enzymic system of cardiomyocytes to act.

[Effect of plant growth regulators, hydrazine derivatives, on the state of the microsomal systems of the liver].

Hydrazine derivatives (Gidrel, Digidrel and DMMH) at a dose of 1/10 (LD50) inhibit microsomal oxidation, decrease superoxide dismutase activity and activate lipid peroxidation in the rat hepatic microsomes. At the same dose level maleic hydrazide has no effect on the indices studied. The role of superoxide-superoxide dismutase system in the mechanism of microsomal oxidation inhibition by hydrazine derivatives is discussed.