Prognostic factors for first recurrence following meningioma surgery.

The present study investigated the role of the Simpson grade system, MIB-1 immunohistochemical marker, meningioma location and grade in the risk of recurrence. Between January, 2008 and January, 2018, the present study retrospectively evaluated all patients undergoing craniotomy for the resection of a histopathologically confirmed meningioma. Patients with neurofibromatosis, acoustic neurinomas and radiation treatment prior to surgery were excluded.

Synergistic Anti-Cancer Effects of Isocnicin and Radiotherapy in Glioblastoma: A Natural Compound's Potential.

Background/objectives: Glioblastoma (GBM) is the most aggressive type of brain tumor in adults. Currently, the only treatments available are surgery, radiotherapy, and chemotherapy based on temozolomide (TMZ); however, the prognosis is dismal. Several natural substances are under investigation for cancer treatment.

Multinodular and Vacuolating Neuronal Tumors of the Cerebrum: A Systematic Review of the Literature.

Multinodular and vacuolating neuronal tumors (MVNTs) of the cerebrum are rare, seizure-related, low-grade tumors of the central nervous system that usually affect young adults. First described by Huse et al. in 2013, these neoplasms are usually located within the deep cortical ribbon and the superficial white matter and have a characteristic cytoarchitecture of cells with neuronal and glial differentiation that form multiple nodules with conspicuous vacuolation.

Natural Compounds and Cancer: Current Evidences.

Natural compounds are constantly gaining ground in the treatment of various chronic diseases and in cancer research. Recent efforts have been focusing on them due to their special features consisting of low toxicity and high bioavailability. These compounds have already demonstrated important antitumor activity against several cancers in vitro through several mechanisms, including cell viability reduction, suppression of cell proliferation, cell death induction and cell cycle arrest.