Publications by authors named "G A Acton"

Commonly reported in dementia, neuropsychiatric symptoms (NPS), cognitive decline, and sleep disturbances indicate dementia progression. With the growing dementia burden, identifying protective factors that may slow dementia progression is increasingly essential. Religion and spirituality are associated with better mental and physical health, yet few studies have been reported in older adults with dementia.

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Protective factors that slow dementia progression and improve quality of life are needed. Neuropsychiatric symptoms (NPS), cognitive decline, and sleep disturbances are commonly found in dementia, indicate progression, and increase caregiver distress. The purpose of this study was to examine the association of private prayer with NPS, cognitive function, and sleep disturbances in older adults with dementia.

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Introduction: Literature on the association of religion and spirituality (R/S) and health is growing. However, it is unclear how R/S affects outcomes and is assessed in persons with dementia (PWDs). In this integrative review, we evaluate published R/S measures and synthesize R/S findings for PWDs.

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Resilience can be defined as the ability of an animal to remain productive in the face of diverse environmental challenges. Several factors contribute to an animal's resilience including its ability to resist disease, cope with climatic extremes and respond to stressors. Immune competence, a proxy trait for general disease resistance, is expected to contribute to an animal's resilience.

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Article Synopsis
  • The study evaluates the effects of PI3Kδ inhibitor AMG319 in patients with head and neck cancer, showing that it reduces regulatory T cells while boosting the activity of tumor-fighting T cells.
  • However, the treatment resulted in significant immune-related adverse events (irAEs) in nearly half of the patients, raising concerns about systemic effects on T cells.
  • Mouse models suggest that altering dosing regimens could reduce these toxic effects while still effectively shrinking tumors, prompting further exploration of treatment strategies.
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