Protocol of the schools program: a type II hybrid implementation-effectiveness trial to increase adolescents' physical activity and reduce sedentary time in secondary schools.

Introduction: Despite the known health and educational benefits of physical activity and the risks of prolonged sedentary behaviour, only one in 10 adolescents globally meet physical activity guidelines, and three-quarters of the school day is spent sitting. , an effective and cost-effective whole-of-school programme for promoting primary school children's physical activity and reducing sedentary behaviour, has been adapted for secondary schools (). The aim of this paper is to describe the protocol for in relation to implementation and scale-up across Australia, and the real-world effectiveness of the intervention on adolescents' physical activity and sedentary time, as well as sitting time, sleep, well-being and class and school engagement.

Digital Home-Based Self-Monitoring System for People with Heart Failure: Protocol for Development of SmartHeart and Evaluation of Feasibility and Acceptability.

Background: Heart failure (HF) is a chronic, progressive condition where the heart cannot pump enough blood to meet the body's needs. In addition to the daily challenges that HF poses, acute exacerbations can lead to costly hospitalizations and increased mortality. High health care costs and the burden of HF have led to the emerging application of new technologies to support people living with HF to stay well while living in the community.

A conifer metabolite corrects episodic ataxia type 1 by voltage sensor-mediated ligand activation of Kv1.1.

Loss-of-function sequence variants in , which encodes the voltage-gated potassium channel Kv1.1, cause Episodic Ataxia Type 1 (EA1) and epilepsy. Due to a paucity of drugs that directly rescue mutant Kv1.