Interleukin-15 and chemokine ligand 19 enhance cytotoxic effects of chimeric antigen receptor T cells using zebrafish xenograft model of gastric cancer.

Chimeric antigen receptor (CAR) T cells have been proven effective for the treatment of B-cell-mediated malignancies. Currently, the development of efficient tools that supply CAR T cells for the treatment of other malignancies would have great impact. In this study, interleukin (IL)-15 and C-C motif chemokine ligand 19 (CCL19) were introduced into natural killer group 2D (NKG2D)-based CARs to generate 15×19 CAR T cells, which remarkably increased T-cell expansion and promoted the production of central memory T (T) cells.

Draft Genome Sequence of Linezolid-Resistant Enterococcus faecalis Clinical Isolate HS0914.

We report the draft genome sequence of linezolid-resistant Enterococcus faecalis strain HS-0914 isolated from a teaching hospital in Shanghai, China. The draft genome sequence is composed of 61 contigs for 2,816,079 bp. Ribosomal RNA mutations and cfr, which mediates linezolid resistance, are not present.