LncRNA FGD5-AS1 Alleviates Inflammation in Allergic Rhinitis through the miR-223-3p/COX11 Axis.

Introduction: Long noncoding RNAs (lncRNAs) have been implicated in the pathogenesis of allergic rhinitis (AR). The current investigation is focused on elucidating the functional impact of a specific lncRNA, FGD5 antisense RNA 1 (FGD5-AS1), on the development and progression of AR through its interaction with miR-223-3p.

Methods: An experimental framework for AR was constructed in both cellular and animal models.

MicroRNA-30a Targets ATG5 and Attenuates Airway Fibrosis in Asthma by Suppressing Autophagy.

Asthma is the most common chronic disease of childhood, chronic airway inflammation; bronchial tissue fibrosis, is a pathological feature common to children asthma, and an emerging data has indicted that autophagy plays critical roles in airway inflammation and fibrosis-mediated airway remodeling. The aim of this study was to examine whether the antifibrotic effect of epithelial microRNAs (miRNAs) relies on regulating autophagy-mediated airway remodeling and to identify the factors involved and the underlying mechanisms. Our results showed miR-30a were downregulated in children with asthma and ovalbumin (OVA) mouse model in parallel with the upregulation of autophagy-related proteins; moreover, we observed miR-30a inhibited the autophagy by downregulated autophagy-related 5 (ATG5).

Application of First-Order Shear Deformation Theory on Vibration Analysis of Stepped Functionally Graded Paraboloidal Shell with General Edge Constraints.

The paper introduces a semi-analytical approach to analyze free vibration characteristics of stepped functionally graded (FG) paraboloidal shell with general edge conditions. The analytical model is established based on multi-segment partitioning strategy and first-order shear deformation theory. The displacement components along axial direction are represented by Jacobi polynomials, and the Fourier series are utilized to express displacement components in circumferential direction.

An exact solution for the free-vibration analysis of functionally graded carbon-nanotube-reinforced composite beams with arbitrary boundary conditions.

We present an exact method to model the free vibration of functionally graded carbon-nanotube-reinforced composite (FG-CNTRC) beams with arbitrary boundary conditions based on first-order shear deformation elasticity theory. Five types of carbon nanotube (CNT) distributions are considered. The distributions are either uniform or functionally graded and are assumed to be continuous through the thickness of the beams.