Publications by authors named "Fuzhao Lu"
Dexmedetomidine has been reported to reduce mortality in septic rats. This study was designed to investigate the effects of dexmedetomidine on inflammatory reaction in lung tissues of septic rats induced by CLP. After induction of sepsis, the rats were treated with normal saline or dexmedetomidine (5, 10, or 20 μg/kg).
View Article and Find Full Text PDFKetamine inhibits lipopolysaccharide-induced astrocytes activation by suppressing TLR4/NF-ĸB pathway.
Cell Physiol Biochem
December 2012
Article Synopsis
- Ketamine shows potential anti-inflammatory effects on astrocytes activated by LPS, but the underlying mechanism is not fully understood.
- Researchers studied how ketamine affects TLR4 expression and NF-ĸB-p65 phosphorylation, as well as proinflammatory cytokine production in astrocytes.
- The findings indicate that ketamine reduces inflammatory responses by lowering TLR4 expression and inhibiting NF-ĸB activation in LPS-stimulated astrocytes.