In this paper, corn starch was used as the base material, and 3-chloro-2-hydroxypropyl trimethyl ammonium chloride was used as a cationic surfactant to modify it. Subsequently, acrylic acid was then used as the primary raw material, and through the combined action of potassium persulfate and N,N'-methylene bisacrylamide, a cationic modified starch grafted acrylic-based water-absorbent resin dust suppressant (CACS) is synthesized via graft polymerization. During the preparation process, the water absorption performance is employed as the key indicator to optimize the process parameters: the degree of neutralization of acrylic acid is set at 50%, the mass ratio of corn starch to acrylic acid is 10 wt%, the volume ratio of CHPTA to acrylic acid is 1:20, the initiator concentration is 0.
View Article and Find Full Text PDFBackground: Differentiating whether hepatic cystic echinococcosis (HCE) lesions exhibit biological activity is essential for developing effective treatment plans. This study evaluates the performance of a Transformer-based fusion model in assessing HCE lesion activity.
Methods: This study analyzed CT images and clinical variables from 700 HCE patients across three hospitals from 2018 to 2023.
Objective: This study developed and validated a stacked ensemble machine learning model to predict the risk of acute kidney injury in patients with acute pancreatitis complicated by sepsis.
Design: A retrospective study based on patient data from public databases.
Participants: This study analysed 1295 patients with acute pancreatitis complicated by septicaemia from the US Intensive Care Database.
Unlabelled: Similar clinical manifestations and imaging features between biliary tract inflammatory lesion (BTI) and biliary tract cancer (BTC) pose significant challenges for the management of BTC. To date, the molecular characteristics of the relationship between biliary tract inflammatory lesion and biliary tract cancer remain poorly elucidated. Here, we performed target deep sequencing on 45 BTC patients and 31 BTI patients based on cell-free DNA (cfDNA) in plasma.
View Article and Find Full Text PDFAs a major type of structural variants, tandem duplication plays a critical role in tumorigenesis by increasing oncogene dosage. Recent work has revealed that noncoding enhancers are also affected by duplications leading to the activation of oncogenes that are inside or outside of the duplicated regions. However, the prevalence of enhancer duplication and the identity of their target genes remains largely unknown in the cancer genome.
View Article and Find Full Text PDFBackground: Electrical impedance tomography (EIT) is a relatively recent functional imaging technique that is both noninvasive and radiation free. EIT measures the associated voltage when a weak current is applied to the surface of the human body to determine the distribution of electrical resistance within tissues. We performed a bibliometrics-based review to explore the geographic hotspots of current research and future trends developing in the field of EIT for mechanical ventilation.
View Article and Find Full Text PDFIntroduction: Atrial fibrillation (AF) is a prevalent cardiac arrhythmia with significant clinical implications. The potential influence of lipid-lowering therapies, specifically PCSK9 inhibitors (PCSK9i) and HMG-CoA reductase inhibitors (statins), on AF risk remains a topic of interest. This mendelian randomization (MR) study aimed to elucidate the causal relationship between genetically predicted inhibition of PCSK9 and HMG-CoA reductase and the risk of AF.
View Article and Find Full Text PDFThe present study investigated the effects of extract (AME) on growth performance, immune response, and energy metabolism of juvenile largemouth bass (). Seven diets containing 0%, 0.1%, 0.
View Article and Find Full Text PDFAs the most outer layer between itself and the environment, integuments are necessary for insects with various important functions. Cuticular proteins (CPs) are the main components in integuments, while the functions of CP genes remain unknown in Mythimna separata (Walker), which is a devastating agricultural pest. In this study, 79 CP genes were identified from the transcriptomes of larval integuments, 57 of which were from the family containing conserved Rebers & Riddiford (R&R) consensus (CPR family).
View Article and Find Full Text PDFPurpose: Environmental factors such as long-term exposure to cold can increase the risk of chronic diseases. However, few studies have focused on the impact of environmental factors and lifestyle changes on chronic diseases. To fully explore the association between exposure to environmental factors and the prevalent risk of various chronic diseases, we conducted a large cohort study (Environment and Chronic Disease in Rural Areas of Heilongjiang, China (ECDRAHC)).
View Article and Find Full Text PDFT-2 toxin is one of the most toxic mycotoxins contaminating various grains. It is considered an environmental risk factor for Kashin-Beck disease (KBD), an endemic degenerative osteochondrosis. Currently, the underlying molecular mechanisms of articular cartilage damage caused by T-2 toxin have not been elucidated.
View Article and Find Full Text PDFGlioblastoma (GBM) is a fatal malignancy caused by dysregulation of cellular signal transduction. Internalization plays a key role in maintaining signalling balance. Previous reports showed that Sortilin related VPS10 domain containing receptor 3 (SorCS3) has the ability to regulate internalization.
View Article and Find Full Text PDFSpermatogonial stem cells (SSCs) are able to undergo both self-renewal and differentiation. Unlike self-renewal, which replenishes the SSC and progenitor pool, differentiation is an irreversible process committing cells to meiosis. Although the preparations for meiotic events in differentiating spermatogonia (Di-SG) are likely to be accompanied by alterations in chromatin structure, the three-dimensional chromatin architectural differences between SSCs and Di-SG, and the higher-order chromatin dynamics during spermatogonial differentiation, have not been systematically investigated.
View Article and Find Full Text PDFJ Anim Sci Biotechnol
December 2021
Background: Spermatogenesis is the process by which male gametes are formed from spermatogonial stem cells and it is essential for the reliable transmission of genetic information between generations. To date, the dynamic transcriptional changes of defined populations of male germ cells in pigs have not been reported.
Results: To characterize the atlas of porcine spermatogenesis, we profiled the transcriptomes of ~ 16,966 testicular cells from a 150-day-old pig testis through single-cell RNA-sequencing (scRNA-seq).
Genomics Proteomics Bioinformatics
August 2023
Spermatogenesis is a continual process that occurs in the testes, in which diploid spermatogonial stem cells (SSCs) differentiate and generate haploid spermatozoa. This highly efficient and intricate process is orchestrated at multiple levels. N-methyladenosine (mA), an epigenetic modification prevalent in mRNAs, is implicated in the transcriptional regulation during spermatogenesis.
View Article and Find Full Text PDFThe traditional guar gum fracturing fluid system has the drawbacks of the fracturing process of unconventional oil and gas deposits, such as high drag resistance and large residuum harm, which is gradually replaced by the system of the slick water fracturing fluid. The conventional slick water system, however, still has the features of low sand-carrying capability. Therefore, high-viscosity slick water is often used in fracturing operations, but most of the high-viscosity slick water is difficult to prepare, dissolve, and break gels, which needs to be improved.
View Article and Find Full Text PDFBreast cancer is the leading cause of tumor-associated death among women worldwide, and new therapeutic strategies are required to improve the post-surgery prognosis and quality of life of patients. Radiofrequency ablation (RFA) is a less invasive approach compared with traditional surgical resection to treat malignancies, and the combination of RFA and chemotherapeutic agents, including formosanin C (FC), can synergistically improve the curative effects against breast carcinoma. However, the detailed mechanisms remain unclear.
View Article and Find Full Text PDFThis study aimed to construct a prognostic ferroptosis-related signature for thyroid cancer and probe into the association with tumor immune microenvironment. Based on the expression profiles of ferroptosis-related genes, a LASSO cox regression model was established for thyroid cancer. Kaplan-Meier survival analysis was presented between high and low risk groups.
View Article and Find Full Text PDFImmunopharmacol Immunotoxicol
April 2021
The present study was aimed to evaluate the anxiolytic and antidepressant-like effects of schizandrin (from (Turcz.) Baill. which is a functional food) against chronic liver injury in mice.
View Article and Find Full Text PDFAcute or chronic liver injury is closely related to hyperammonemia, which will result in oxidative stress and damage to nerve cells, and these factors are vital to the development of anxiety and depression. In this study, the effect of Nootkatone (NKT) on the anxiety- and depression-like behavioral changes in mice induced by liver injury was investigated. Liver injury was induced by D-galactosamine (D-GalN; 350 mg/kg) three times a week for 4 weeks.
View Article and Find Full Text PDFThe present study was aimed to investigate the mechanisms of salidroside (SAL) from Rhodiola wallichiana var. cholaensis on hypoglycemic and oxidative stress responses. The palmitate (PA)-induced GLUTag cells model and the glucosamine-induced insulin resistance model in HepG2 cells were built.
View Article and Find Full Text PDFPurpose: To explore the associations of computed tomography (CT) features with tumor-node-metastasis (TNM) stage and pathology of patients with rectal cancer and their significance in the evaluation of efficacy and prognosis.
Methods: A total of 83 rectal cancer patients who were operated in our hospital were collected. CT examination was performed before operation, and pathological examination was conducted after operation.
Water hyacinth is considered to be among the worst invasive weed species globally, causing detrimental environmental and social problems worldwide. It rapidly grows, and therefore has significant potential as a resource. Due to its high moisture content (approximately 95%), the by-product obtained by dehydrating water hyacinth yields a considerable amount of water hyacinth juice (WHJ).
View Article and Find Full Text PDFBackground: Spermatogonial stem cells (SSCs), as tissue-specific stem cells, are capable of both self-renewal and differentiation and supporting the continual and robust spermatogenesis for male fertility. As a rare sub-fraction of undifferentiated spermatogonia, SSCs share most molecular markers with the progenitor spermatogonia. Thus, the heterogeneity of the progenitor cells often obscures the characteristics of stem cells.
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