A new pair of butylphthalide diastereomers from the roots of .

A new pair of butylphthalide diastereomers, dangguinolide A () and dangguinolide B (), together with two known butylphthalide were isolated from . Their structures were determined by extensive spectroscopic analyses, and the absolute configurations of and were assigned NMR calculations and ECD calculations. Their anti-inflammatory activities have evaluated .

A novel Alisma orientale extract alleviates non-alcoholic steatohepatitis in mice via modulation of PPARα signaling pathway.

Non-alcoholic fatty liver disease (NAFLD), particularly advanced non-alcoholic steatohepatitis (NASH), leads to irreversible liver damage. This study investigated the therapeutic effects and potential mechanism of a novel extract from traditional Chinese medicine Alisma orientale (Sam.) Juzep (AE) on free fatty acid (FFA)-induced HepG2 cell model and high-fat diet (HFD) + carbon tetrachloride (CCl)-induced mouse model of NASH.

Three undescribed coumarins from the roots of .

Three undescribed coumarins, 6-(3-hydroxy-3-methyl-2-oxobutyl)-7-methoxycoumarin (), (R)-6-(1,3-dihydroxy-3-methyl-2-oxobutyl)-7-methoxycoumarin (), angelol N (), together with four known coumarins were isolated from the roots of . Their structures were determined by extensive spectroscopic analyses. The absolute configurations of compounds and were assigned electronic circular dichroism (ECD).

A new butylphthalide from DC.

One new butylphthalide ligusticumolide H (), together with the known butylphthalides senkyunolide I (), senkyunolide H (), (3 ,3')-3'-hydroxy-3-butylphthalide (), (3 )-4-hydroxy-3-butylphthalide () and senkyunolide C () was isolated from the rhizome of DC. Their structures were determined by extensive spectroscopic analyses including HR-ESI-MS, 1D and 2D NMR, and the absolute configuration of was established by NMR and ECD calculations. Their effect on NO production in IL-1β-stimulated chondrocytes was also evaluated.

Four new flavonol glycosides from the leaves of .

Four new flavonol glycosides, 5, 7, 5'-trihydroxy-3', 4'-dimethoxyflavonol-3---L-rhamnopyranosyl-(1→6)--D-glucopyranoside (), quercetin 3--(6--feruloyl)--D-glucopyranosyl-(1→2)--L-rhamnopyranoside (), kaempferol 3--(6--caffeoyl)--D-glucopyranosyl-(1→2)--L-rhamnopyranoside (), myricetin 3--(6---coumaroyl)--D-glucopyranosyl-(1→2)--L-rhamnopyranoside (), together with nine known flavonoids and two known lignans, were isolated from the leaves of . Their structures were determined by extensive spectroscopic analyses. Their cardioprotective effects against HO-induced apoptosis in H9c2 cells were also evaluated.

A new ferulic acid ester from Rhodiola wallichiana var. cholaensis (Crassulaceae).

A new ferulic acid ester, 6-feruloyloxyhexanoic acid (1), was isolated along with 10 known ones (2-11), from the concentrated water extract of Rhodiola wallichiana var. cholaensis. Their chemical structures were elucidated on the basis of extensive spectroscopic methods including Two-dimensional nuclear magnetic resonance (2D NMR) experiments.

[Application of molecularly imprinted technology for separation of PGG from Guizhi Fuling capsule].

1,2,3,4,6-penta-O-galloyl-D-glucose (PGG) is one of the main active compounds of Guizhi Fuling capsule. Molecularly imprinted polymers (MIP) have high affinity toward template molecules synthesized by molecularly imprinted technology for its specific combined sites, which can overcome the shortcoming of traditional separation methods, such as complex operation, low efficiency, using large quantity of solvent and environmental pollution. In this paper, surface molecularly imprinted polymer (SMIP) was prepared by surface imprinting with PGG as the template molecule.

A new flavonol glycoside from the florets of Carthamus tinctorius L.

One new flavonol glycoside, 6-hydroxykaempferol-3-O-β-D-glucoside-7-O-β-D-glucuronide (1), together with eight known flavonoids and three known quinochalcones, was isolated from the florets of Carthamus tinctorius L. Their structures were determined by extensive spectroscopic analyses. Their cardioprotective effects against H2O2-induced apoptosis in H9c2 cells were also evaluated; compounds 1, 2, 4-5, 7-10 and 12 provided significant protective effects on H2O2-induced H9c2 cells at the concentration of 25 μg/mL.

[Anti-complementary phenolic acids from Lonicera japonica].

Objective: To study the anti-complementary phenolic acids from Lonicera japonica.

Method: The anti-complementary activity-directed isolation was carried out with the hemolysis test as guide. All isolation was evaluated for their in vitro anti-complementary activities.

[Chemical constituents from Artemisia annua].

Objective: To investigate the chemical constituents of dried whole plants of Artemisia annua.

Method: The chemical constituents were isolated by repeated silica gel chromatography, medium pressure column chromatography, and semi-preparative HPLC, and their structures were elucidated by spectroscopic analyses and comparison of NMR data with those reported in literature.

Result: 15 compounds were isolated and identified to be 5-O-[(E)-Caffeoyl] quinic acid(l), 1,3-di-O-caffeoylquinic acid(2), 4 5-di-O-caffeoylquinic acid(3), 3, 5-di-O-caffeoylquinic acid (4), 3, 4-di-O-caffeoylquinic acid (5), methyl-3,4-di-O-caffeoylquinic acid(6), methyl-3,5-di-O-caffeoylquinic acid(7), 3,6'-O-diferuloylsucrose(8), 5'-β-D-glucopyranosyloxyjasmonic acid(9), Scopoletin(10), scoparone (11), 4-O-β-D-glucopyranosyl-2-hydroxyl-6-methoxyacetophenone (12), chrysosplenol D (13), casticin (14), chrysosplenetin(15).