The complete mitochondrial genome of Thomas, 1907 (Rodentia: Sicistidae) and its phylogenetic analyses.

This study aimed to examine the complete mitogenome sequence of Thomas, 1907. A circular double-stranded structure made up the mitochondrial genome of . The complete length of the mitochondrial genome was 16,629 bp.

Identification and validation of three potential biomarkers and immune microenvironment for in severe asthma in microarray and single-cell datasets.

The aim of this study was to identify genetic biomarkers and cellular communications associated with severe asthma in microarray data sets and single cell data sets. The potential gene expression levels were verified in a mouse model of asthma. We identified differentially expressed genes from the microarray datasets (GSE130499 and GSE63142) of severe asthma, and then constructed models to screen the most relevant biomarkers to severe asthma by machine learning algorithms (LASSO and SVM-RFE), with further validation of the results by GSE43696.

Exploring the therapeutic mechanisms of Sijunzi decoction in the treatment of sarcopenia: Key targets and signaling pathways.

Sarcopenia, an age-associated condition, negatively impacts the quality of life. This study investigates the mechanism of Sijunzi decoction (SJZD), a traditional Chinese formula, against sarcopenia. Active compounds and potential targets of SJZD for sarcopenia were gathered from databases.

Characteristics of organic pollutants and their effects on the microbial composition and activity in the industrial soils of Pearl River Delta, China.

To investigate the interaction between organic pollutants and soil microorganisms, industrial soils were collected from Pearl River Delta region of China for determining semi-volatile organic pollutants, the community structure and activity of microorganisms. The results showed that polycyclic aromatic hydrocarbons (PAHs) (63.3-4956 μg kg) and phthalate esters (PAEs) (272-65,837 μg kg) were main organic pollutants in the research area soils.

Contribution of dicarboxylic acids to pyrene biodegradation and transcriptomic responses of Enterobacter sp. PRd5.

The colonization of degrading endophytic bacteria is an effective means to reduce the residues of polycyclic aromatic hydrocarbons (PAHs) in crops. Dicarboxylic acids, as the main active components in crops, can affect the physiological activities of endophytic bacteria and alter the biodegradation process of PAHs in crops. In this study, malonic acid and succinic acid were selected as the representatives to investigate the contribution of dicarboxylic acids to pyrene biodegradation by endophytic Enterobacter sp.

Afterglow Implant for Arterial Embolization and Intraoperative Imaging.

Transcatheter arterial embolization (TAE) is wildly used in clinical treatments. However, the online monitoring of the thrombosis formation is limited due to the challenges of the direct visualization of embolic agents and the real-time monitoring of dynamic blood flow. Thus, we developed a photochemical afterglow implant with strong afterglow intensity and a long lifetime for embolization and imaging.

Chinese Stroke Center Alliance: a national effort to improve healthcare quality for acute stroke and transient ischaemic attack: rationale, design and preliminary findings.

Background: In June 2015, the Chinese Stroke Association (CSA) initiated the Chinese Stroke Center Alliance (CSCA) to establish the national hospital-based stroke care quality assessment and improvement platform. This article outlines its objectives, operational structure, patient population, quality improvement (QI) intervention tools, data elements, data collection methodology and current patient and hospital data.

Methods: The CSCA is a national, hospital-based, multicentre, voluntary, multifaceted intervention and continuous QI initiative.

Inhibition of 5-lipoxygenase and cyclooxygenase-2 pathways by pain-relieving plaster in macrophages.

Context: Pain-relieving plaster (PRP) is a traditional Chinese medicine (TCM) that has been widely used with satisfactory results in the treatment of some diseases related to inflammation, such as bruises, chronic arthritis.

Objective: The mechanisms underlying the anti-inflammatory actions of PRP are investigated in this study for the first time.

Materials And Methods: The anti-inflammatory effects of PRP extracts were evaluated in lipopolysaccharide (LPS) or calcium ionophore A23187-treated murine peritoneal macrophages (PMs).

Effect of ginkgolide B on the platelet-activating factor induced changes of chemotaxis and cytoskeleton of macrophages.

Aim: To study the inhibitory effect of ginkgolide B (BN52021) on the PAF induced changes of chemotaxis of murine peritoneal macrophages and the related polymerization of F-actin.

Methods: Chemotaxis assays were performed using a modified 48-well Boyden chamber. Actin polymerization of murine peritoneal macrophages was analyzed by flow cytometry using a specific fluorescent stain.