Publications by Fuyin Deng

Publications by authors named "Fuyin Deng"

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Expansion of peripheral cytotoxic CD4+ T cells in Alzheimer's disease: New insights from multi-omics evidence.

Jiongxue Chen Jiatian Xie Fuyin Deng Jinhua Cai Sitai Chen

Genomics

January 2025

The significance of the adaptive immune response in Alzheimer's disease (AD) is increasingly recognized. We analyzed scRNA-Seq data from AD patients, revealing a notable rise in CD4 cytotoxic T cells (CD4-CTLs) in peripheral blood mononuclear cells (PBMCs), validated in vivo and in vitro. This rise correlates with cognitive decline in AD patients.

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