Publications by authors named "Fuyi Chen"

Formate has emerged as a promising energy carrier to generate electrons via formate oxidation reaction (FOR) and hydrogen via formate dehydrogenation reaction (FDR), and it is desirable but difficult to design a novel bifunctional (electro)catalyst to improve reaction kinetics. Herein, we construct the single-twinned AgPdIr (t-AgPdIr) nanoalloy to improve the catalytic activity and stability for the formate oxidation and dehydrogenation processes. The t-AgPdIr nanoalloy, characterized by a distinctive twinned structure with strains and a downshift of the d-band center, demonstrates an improved peak current density of 4.

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The heterogeneity of stem cells is a significant factor inhibiting their clinical application, as different cell subpopulations may exhibit substantial differences in biological functions. We performed single-cell sequencing on HUMSCs from three donors of different gestational ages (22 + 5 weeks, 28 weeks, 39 weeks). We also compared the data with single-cell sequencing data from BMSCs from two public databases.

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Carbohydrate-protein interactions play fundamental roles in numerous aspects of biological activities, and the search for new carbohydrate (CHO)-binding proteins (CBPs) has long been a research focus. In this study, through the analysis of CBP structures, we identified significant enrichment of aromatic residues in CHO-binding regions. We further summarized the structural features of these aromatic rings within the CHO-stacking region, namely "exposing" and "proximity" features, and developed a screening algorithm that can identify CHO-stacking Trp (tryptophan) residues based on these two features.

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irGSEA is an R package designed to assess the outcomes of various gene set scoring methods when applied to single-cell RNA sequencing data. This package incorporates six distinct scoring methods that rely on the expression ranks of genes, emphasizing relative expression levels over absolute values. The implemented methods include AUCell, UCell, singscore, ssGSEA, JASMINE and Viper.

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The design of heterogeneous catalysts generally involves optimizing the reactivity descriptor of adsorption energy, which is inevitably governed by the structure of surface-active sites. A prerequisite for understanding the structure-properties relationship is the precise identification of real surface-active site structures, rather than relying on conceived structures derived from bulk alloy properties. However, it remains a formidable challenge due to the dynamic nature of nanoalloys during catalytic reactions and the lack of accurate and efficient interatomic potentials for simulations.

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Optogenetic manipulation with single-cell resolution can be achieved by two-photon excitation. However, this frequently requires relatively high laser powers. Here, we developed a novel strategy that can improve the efficiency of current two-photon stimulation technologies by positioning fluorescent proteins or small fluorescent molecules with high two-photon cross-sections in the vicinity of opsins.

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AgPd nanoalloys often undergo structural evolution during catalytic reactions; the mechanism underlying such restructuring remains largely unknown due to the use of oversimplified interatomic potentials in simulations. Herein, a deep-learning potential is developed for AgPd nanoalloys based on a multiscale dataset spanning from nanoclusters to bulk configurations, exhibits precise predictions of mechanical properties and formation energies with near-density functional theory accuracy, calculates the surface energies closer to experimental values compared to those obtained by Gupta potentials, and is applied to investigate the shape reconstruction of single-crystalline AgPd nanoalloys from cuboctahedron (Oh) to icosahedron (Ih) geometries. The Oh to Ih shape restructuring is thermodynamically favorable and occurs at 11 and 92 ps for Pd55@Ag254 and Ag147@Pd162 nanoalloys, respectively.

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Formate is a promising hydrogen carrier for safe storage and transport and a fuel for direct formate fuel cells. However, the sluggish kinetics of catalysts for formate dehydrogenation (FDH) and oxidation reactions (FORs) significantly limit the potential applications of formate. Strain effects can effectively modulate catalytic properties by altering the electronic structure.

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Article Synopsis
  • The study examines the potential of human umbilical cord Wharton's Jelly-derived mesenchymal stem cells (HUMSCs) as a treatment for complications in extremely preterm infants, compared to term infants.
  • Researchers isolated HUMSCs from both extremely preterm (22 to 28 weeks) and term infants (39 weeks) and analyzed their properties, such as proliferation rate and the expression of specific markers.
  • Findings indicate that HUMSCs from extremely preterm infants have a higher proliferation rate and are more effective in promoting healing in damaged cells, suggesting their potential for use in cell therapy for preterm infants.
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The study provides a proof of concept for the first time that unique palladium-gold (PdAu) and palladium-silver (PdAg) nanodendrites are bifunctional catalytic active sites for formate oxidation reactions (FORs) and formate dehydrogenation reactions (FDRs). The unique nanodendritic structure was developed a simple galvanic displacement reaction for the direct growth of PdAu and PdAg nanodendrites on a nickel foam (PdAu/NiNF and PdAg/NiNF). These PdAu/NiNF and PdAg/NiNF electrodes exhibited 2.

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The methanol oxidation reaction (MOR) is crucial in many energy-conversion devices. Although intensive efforts have been devoted to improving the MOR catalytic activity of Pt-based catalysts by treatment or alloying, enhancing the MOR catalyst performance utilizing solar energy has been less investigated. PtAg nanoalloys, combining the intrinsic catalytic activity of Pt toward the MOR with the visible spectrum plasmonic response of Ag, are expected to be a good MOR catalyst for solar energy, however, it remains challenging to incorporate these immiscible elements into a nanoalloy in a controlled way using conventional synthetic techniques.

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This review introduces recent advances of various anion-mixed transition metal compounds (e.g., nitrides, halides, phosphides, chalcogenides, (oxy)hydroxides, and borides) for efficient water electrolysis applications in detail.

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Given the critical demands on energy conversion, storage, and transportation, tremendous interest has been devoted to the field of material development related to energy harvesting, recently. As the only route towards energy utilization, the carriers with the characteristics of low carbon are regarded as the future choice, , hydrogen and ammonia. To this end, electrocatalysis provides a green way to access these substances.

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Purpose: The association between maternal vitamin D concentrations and birth weight is controversial. We conducted a large-scale retrospective cohort study in southern China to explore this relationship.

Methods: From July 2017 to April 2019, we enrolled 10,586 pregnant women and measured serum vitamin D [ 25-hydroxyvitamin D, 25(OH)D] in the second trimester using electrochemiluminescence immunoassays.

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Multispecific antibodies, often composed of three to five polypeptide chains, have become increasingly relevant in the development of biotherapeutics. These molecules have mechanisms of action that include redirecting T cells to tumors and blocking multiple pathogenic mediators simultaneously. One of the major challenges for asymmetric multispecific antibodies is generating a high proportion of the correctly paired antibody during production.

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Cell death is prevalent throughout life; however, the coordinated interactions and roles of phagocytes during corpse removal in the live brain are poorly understood. We developed photochemical and viral methodologies to induce death in single cells and combined this with intravital optical imaging. This approach allowed us to track multicellular phagocytic interactions with precise spatiotemporal resolution.

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High-performance Pd-based nanocatalysts for alkaline methanol and formate fuel cells have stimulated widespread attention. Hence, a series of ternary Pd-Au-Ag nanoalloys have been synthesized on carbon nanotubes, which demonstrate promising activity and unexpectedly high stability for the formate oxidation reaction (FOR) in alkaline medium. The ternary Pd3Au3Ag1 nanoalloy catalyst showed an initial mass activity of 4.

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Promoting the formate oxidation reaction (FOR) is central to develop promising direct formate fuel cells, but current electrocatalysts are suffering from low activity and ultrapoor stability. Herein, the ternary PdAgRh nanoalloys with ultrathin two-dimensional architecture are for the first time synthesized and employed as a novel class of electrocatalysts for the FOR. Benefitting from unique nanostructure as well as oxophilic Rh surface oxides, the PdAgRh/C electrocatalyst demonstrates an exceptional FOR activity of 1.

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Formate is a kind of carbon-neutral fuel that can be synthesized by electrochemical conversion of CO, however, the generated aqueous formate electrolyte is still short of potential application. Here, formate solution is proposed to be utilized as anode fuels of direct formate fuel cells through the formate oxidation reaction (FOR), and graphene supported AgPd nanoalloys (AgPd/rGO) are prepared to catalyze the FOR. Specifically, the mass activity of the as-prepared AgPd/rGO catalyst is 4.

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The large-scale practical application of formate oxidation reaction (FOR) catalysts is hindered by their low activity and high cost. Herein, for the first time, a series of Pd-doped Ag dilute nanoalloys is demonstrated to have high catalytic activity in FOR with reduced consumption of Pd metals through density functional theory calculations, where the effects of potential, solvent and spin on catalytic performance are discussed. The Pd1Ag(111) single-atom alloy (SAA) exhibits higher FOR catalytic activity as reflected by the low limiting potential of 0.

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Engineering nanoparticle surfaces driven by various gas atmospheres has attracted intensive attention in the design of efficient electrocatalysts for sustainable energy applications. However, the development of a more facile and efficient in situ engineering strategy under electrochemical testing conditions to achieve surface-reconstruction-induced high performance is significantly lacking. Herein, for the first time, we report in situ high-potential-driven restructuring in ternary AgPdPt aerogels with dilute Pt (AgPd-Ptdilute) during the electrochemical cyclic voltammetry testing for the alkaline formate oxidation reaction (FOR), in which the upper potential limit is ingeniously extended to the Ag redox region.

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