Synthesis, fungicidal activity and molecular docking of novel pyrazole-carboxamides bearing a branched alkyl ether moiety.

Succinate dehydrogenase inhibitors are essential fungicides used in agriculture. To explore new pyrazole-carboxamides with high fungicidal activity, a series of N-substitutedphenyl-3-di/trifluoromethyl-1-methyl-1H-pyrazole-4-carboxamides bearing a branched alkyl ether moiety were designed and synthesized. The in vitro bioassay indicated that some target compounds displayed appreciable fungicidal activity.

Combination of structure-performance and shape-performance relationships for better biphasic release in electrospun Janus fibers.

In nature, the combination of composition, structure, and shape determines the matter's functional performance to a large extent. Inspired by which, two electrospun Janus nanofiber formulations were created using side-by-side electrospinning in this work. Tamoxifen citrate (TAM) was used as a model drug and ethyl cellulose (EC) and polyvinylpyrrolidone K60 (PVP) as the polymer carrier matrices.

Comparative study of electrospun crystal-based and composite-based drug nano depots.

Complex nanostructures are increasingly becoming important in the development of novel functional nanomaterials. Nano drug depots, characterized by core-shell structures with core drug reservoirs, are drawing increasing attention because of its potential applications in furnishing drug-sustained release profiles. In the present study, two kinds of nano drug depots, one containing a crystal drug reservoir and the other having a medicated composite drug reservoir, were prepared through modified triaxial electrospinning.

Efficient alkaloid capture from water using a charged porous organic polymer.

Berberine hydrochloride (BH), an important alkaloid, can be captured from water and released in organic solution circularly by a charged porous polymer (TPB-HCP), which is hypercross-linked using the cost-effective Friedel-Crafts reaction using sodium tetraphenylborate as the monomer. With high BET surface area, hierarchical porous structure and charged characteristics, TPB-HCP displays excellent adsorption capacity for BH owing to the synergistic effects of size matching and electrostatic interaction.

[Synthesis, characterization and relaxivity of dimeric DTPA-gadonium (III) complexes with long chain alkyl esters of L-lysine].

To look for new MRI (magnetic resonance imaging) contrast agents with higher relaxivity as well as liver-selecsivity, four novel ester-amino ligands were synthesized by bis-acylation of octadecanyl, hexadecanyl, tetradecanyl and dedecanyl L-lysine with diethylenetriaminepentaacetic acid mono-anhydride (DTPA-MA), respectively. The corresponding dimeric Gd(III) complexes were gained by the reaction of these ligands with GdCl3 x 6H2O. All ligands and complexes were characterized by FTIR, 1H NMR and elemental analysis.