Publications by authors named "Fusheng Yang"

The species-rich cosmopolitan genus Rhododendron offers a good system for exploring the genomic mechanisms underlying adaptation to diverse habitats. Here, we report high-quality chromosomal-level genome assemblies of nine species, representing all five subgenera, different altitudinal distributions, and all flower color types of this genus. Further comprehensive genomic analyses indicate diverse adaptive strategies employed by Rhododendron, particularly adaptation to alpine and subalpine habitats by expansion/contraction of gene families involved in pathogen defense and oxidative phosphorylation, genomic convergent evolution, and gene copy-number variation.

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Finding novel energetic materials with good comprehensive performance has always been challenging because of the low efficiency in conventional trial and error experimental procedure. In this paper, we established a deep learning model with high prediction accuracy using embedded features in Directed Message Passing Neural Networks. The model combined with high-throughput screening was shown to facilitate rapid discovery of fused [5,5] biheterocyclic energetic materials with high energy and excellent thermal stability.

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High mountains harbor a considerable proportion of biodiversity, but we know little about how diverse plants adapt to the harsh environment. Here we finished a high-quality genome assembly for Dasiphora fruticosa, an ecologically important plant distributed in the Qinghai-Tibetan Plateau and lowland of the Northern Hemisphere, and resequenced 592 natural individuals to address how this horticulture plant adapts to highland. Demographic analysis revealed D.

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All-hydrogel supercapacitors are emerging as promising power sources for next-generation wearable electronics due to their intrinsic mechanical flexibility, eco-friendliness, and enhanced safety. However, the insufficient interfacial adhesion between the electrode and electrolyte and the frozen hydrogel matrices at subzero temperatures largely limit the practical applications of all-hydrogel supercapacitors. Here, an all-hydrogel supercapacitor is reported with robust interfacial contact and anti-freezing property, fabricated by in situ polymerizing hydrogel electrolyte onto hydrogel electrodes.

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Solid-state zinc-ion capacitors are emerging as promising candidates for large-scale energy storage owing to improved safety, mechanical and thermal stability and easy-to-direct stacking. Hydrogel electrolytes are appealing solid-state electrolytes because of eco-friendliness, high conductivity and intrinsic flexibility. However, the electrolyte/electrode interfacial contact and anti-freezing properties of current hydrogel electrolytes are still challenging for practical applications of zinc-ion capacitors.

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Reconstructing a robust species phylogeny and disentangling the evolutionary and biogeographic history of the gymnosperm genus Ephedra, which has a large genome and rich polyploids, remain a big challenge. Here we reconstructed a transcriptome-based phylogeny of 19 diploid Ephedra species, and explored evolutionary reticulations in this genus represented by 50 diploid and polyploid species, using four low-copy nuclear and nine plastid genes. The diploid species phylogeny indicates that the Mediterranean species diverged first, and the remaining species split into three clades, including the American species (Clade A), E.

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Unlabelled: Patients with H3K27M-mutant diffuse midline glioma (DMG) have no proven effective therapies. ONC201 has recently demonstrated efficacy in these patients, but the mechanism behind this finding remains unknown. We assessed clinical outcomes, tumor sequencing, and tissue/cerebrospinal fluid (CSF) correlate samples from patients treated in two completed multisite clinical studies.

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Demonstrating the process of transregional biogeography and mechanisms underlying evolutionary radiations is crucial to understanding biological evolution. Here, we use Hydrangeeae (Hydrangeaceae), a tribe with a unique disjunct distribution and complex trait variations, using a solid phylogenetic framework, to investigate how geographical and climatic factors interact with functional traits to trigger plant evolutionary radiations. We constructed the first highly supported and dated phylogenetic framework using 79 protein-coding genes obtained from 81 plastomes, representing 63 species and all major clades, and found that most extant species originated from asynchronous diversification of two lineages undergoing repeated expansion and retraction, at middle and high latitudes of the Northern Hemisphere between East Asia and North America, during the Eocene to Pleistocene (driven by geologic and climatic dynamics).

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Article Synopsis
  • The decline of traditional fossil fuels raises concerns about an impending energy crisis, prompting the exploration of hydrogen from renewable sources as a cleaner energy solution.
  • Hydrogen storage and liquid organic hydrogen carrier technology are crucial for effectively utilizing hydrogen energy, requiring high-performance and cost-effective catalysts for broader application.
  • Recent advancements in catalysts for liquid organic hydrogen carriers involve optimizing support materials and metal interactions, with insights into catalytic mechanisms and future development directions discussed.
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  • Diffuse midline gliomas (DMGs), including DIPGs with H3K27M mutations, are aggressive childhood brain tumors characterized by altered histone modifications that impact gene expression.* -
  • The study found that these mutations increase levels of specific SWI/SNF complex proteins, which help regulate chromatin structure and gene activation, making them potential targets for treatment.* -
  • A targeted therapeutic approach using PROTAC compounds to degrade these proteins resulted in cell death in H3K27M mutant cells, suggesting a promising strategy for combating these lethal cancers.*
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The genus (Ericaceae), with more than 1000 species highly diverse in flower color, is providing distinct ornamental values and a model system for flower color studies. Here, we investigated the divergence between two parental species with different flower color widely used for azalea breeding. Gapless genome assembly was generated for the yellow-flowered azalea, .

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Alzheimer's disease (AD) is a common cognitive disorder. Recently, many computer-aided diagnostic techniques have been used for AD prediction utilizing deep learning technology, among which graph neural networks have received increasing attention owing to their ability to model sample relationships on large population graphs. Most of the existing graph-based methods predict diseases according to a single model, which makes it difficult to select an appropriate node embedding algorithm for a certain classification task.

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Tumor-associated macrophages (TAM) and cancer-associated fibroblasts (CAF) and their precursor mesenchymal stromal cells (MSC) are often detected together in tumors, but how they cooperate is not well understood. Here, we show that TAM and CAF are the most abundant nonmalignant cells and are present together in untreated human neuroblastoma (NB) tumors that are also poorly infiltrated with T and natural killer (NK) cells. We then show that MSC and CAF-MSC harvested from NB tumors protected human monocytes (MN) from spontaneous apoptosis in an interleukin (IL)-6 dependent mechanism.

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Article Synopsis
  • - The study investigates the history of allopolyploidization in Ericales, a diverse group of flowering plants, integrating data from about 200 species to understand their evolutionary background.
  • - Researchers found that Ericales originated from ancient hybridizations and experienced significant gene loss after polyploidization, which affects genetic diversity.
  • - This research proposes a new hypothesis about how Ericales evolved and emphasizes that gene loss plays a crucial role in their genetic variation and adaptation.
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Article Synopsis
  • There are two types of childhood ependymomas: group A (PFAs) and group B (PFBs), and PFAs are harder to treat and have worse outcomes.
  • PFAs have a special protein called EZHIP, which makes some important changes in the cells that help the cancer grow faster.
  • Using a medicine called metformin, which is usually for diabetes, can help slow down the growth of these tumors by changing how the cancer cells use energy and by reducing the EZHIP protein.
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Azaleas (Ericaceae) comprise one of the most diverse ornamental plants, renowned for their cultural and economic importance. We present a chromosome-scale genome assembly for Rhododendron simsii, the primary ancestor of azalea cultivars. Genome analyses unveil the remnants of an ancient whole-genome duplication preceding the radiation of most Ericaceae, likely contributing to the genomic architecture of flowering time.

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Neocaridina denticulate sinensis is a small freshwater economic shrimp, as well as excellent laboratory model for their short life cycle and easy availability. However, the response of N. denticulate sinensis to pervasive copper pollution in aquatic environments has not been deeply investigated yet.

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Article Synopsis
  • * Research indicates that these mutated cells undergo enhanced metabolic processes like glycolysis and glutaminolysis, leading to increased production of alpha-ketoglutarate (α-KG), which helps sustain the low H3K27me3 levels.
  • * Disrupting the metabolic pathways that maintain this epigenetic state shows promising results in improving survival in animal models, highlighting potential new therapeutic strategies for treating H3K27M DIPGs.
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CRISPR/Cas9 technology is an efficient genome editing tool for producing genetically modified animals. Carotenoids color the world around us and their accumulation in animals could be used to culture colorful new verities in animal breeding. β, β-carotene 9', 10'-oxygenase (BCO2) is an important enzyme during β-carotene metabolism.

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During the immune defense reaction of invertebrate, a plenty of reactive oxygen species (ROS) could be induced to product. Though ROS can kill foreign invaders, the accumulation of these reactive molecules in animals will cause serious cell damage. Carotenoids could function as scavengers of oxygen radicals.

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Magnesium borohydride (Mg(BH)) has been considered as a potential material for hydrogen storage. In this paper, density functional theory studies have been carried out on native point defects and electrically active impurities (Ni and Ti) in Mg(BH). A detailed analysis of the geometrical structures, energetics and migration of the defects reveals that hydrogen related defects are charged and their formation energies are Fermi-level dependent.

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Meconopsis (Papaveraceae) is an interesting alpine herb, mainly distributed in the mountainous area of southwest China and high altitude zone in Tibetan-Himalaya. Different Meconopsis species showed a flower color alteration in different anthesis stages, Meconopsis 'Lingholm' is one of the localized species whose petal color changes from purple to blue during the flowering process. In general, the blue color flower is a rare kind, and usually hard to cultivate artificially.

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