Comparison of aneuploidy for patients of different ages treated with progestin-primed ovarian stimulation or GnRH antagonist protocols.

Research Question: Does euploidy status differ among patients of different ages treated with progestin-primed ovarian stimulation (PPOS) or gonadotrophin releasing hormone antagonist (GnRH-a) protocols?

Design: Patients undergoing PGT-A (n = 418; 440 cycles) were enrolled and grouped according to female age (<35 years and ≥35 years). Protocols were as follows: PPOS: <35 years (n = 131; 137 cycles); ≥35 years (n = 72; 80 cycles); GnRH-a: <35 years (n = 149; 152 cycles); ≥35 years (n = 66; 71 cycles).

Results: For cycles treated with PPOS in the older group, rates of euploid blastocyst per metaphase Ⅱ oocyte (15.

Graphitic carbon nitride supported Ni-Co dual-atom catalysts beyond Ni(Co) single-atom catalysts for hydrogen production: a density functional theory study.

Using density functional theory calculations we investigate the formation, structure and electronic properties of gh-CN-supported Ni-Co (Ni-Co/gh-CN) dual-atom catalysts and Ni(Co) single-metal catalysts, as a paradigmatic example of single-atom few-atom catalysts. An inverted mold assumption is proposed to identify the factors determining the number, shape and packing manner of metal atoms inside the pores of gh-CN. The area matching between virtual fragments and metal fillers and lattice inheritance from N coordination and metal aggregates allow for a stable Ni-Co/gh-CN, which would possess more active sites and a more complex structure-activity relation than single-atom doping.

Decreased GDF9 and BMP15 in follicle fluid and granulosa cells and outcomes of IVF-ET among young patients with low prognosis.

Purpose: To analyze the level of growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) in follicle fluid (FF) and granulosa cells (GCs) derived from young patients with low prognosis for in vitro fertilization and embryo transfer (IVF-ET) treatment.

Methods: A prospective cohort study was carried out by enrolling 52 young patients with low prognosis according to the POSEIDON classification group 3 (low prognosis group) and 51 young patients with normal ovarian reserve (control group). The concentration of the GDF9 and BMP15 proteins in FF was determined by enzyme-linked immunosorbent assay.