Publications by authors named "Furu Liu"
Background: Patients with bipolar disorder (BD) show abnormalities in glucolipid metabolism and reproductive hormone levels, which are of concern in women with BD. This study was dedicated to investigating the glucolipid and reproductive hormone levels of female patients, and to preliminarily investigating their relationships with cognition.
Methods: A total of 58 unmedicated female BD patients, 61 stable-medicated female BD patients, and 63 healthy controls (HC) were recruited in this study.
Article Synopsis
- Dopamine plays a significant role in glucose regulation, and high fasting blood glucose levels are positively linked to negative symptoms in first-episode schizophrenia patients.
- Intermittent theta burst stimulation (iTBS) targeting the prefrontal cortex can improve both glucose metabolism and negative symptoms in these patients.
- In animal studies, inhibiting dopamine projections in specific brain areas resulted in glucose intolerance, corroborating the hypothesis that dopamine deficits may contribute to glucose metabolism issues in schizophrenia.
Background: Little is known about the laboratory variable risks with bone mineral density (BMD) in patients with schizophrenia. This study was designed to fully investigate the related risk factors for decreased BMD in schizophrenia, as well as evaluate the gender difference of BMD.
Method: The BMD of the forearm of 211 patients (males/females = 140/71) who met the diagnostic criteria for DSM-5 schizophrenia was measured by dual-energy X-ray absorptiometry.
Article Synopsis
- The study examined the stability of mental disorder diagnoses among psychiatric inpatients over a decade (2011-2020) and identified factors influencing diagnostic consistency.
- A total of 20,359 patients were assessed, revealing a significant decrease in schizophrenia diagnoses and an increase in depression diagnoses, with 92.6% of initial diagnoses maintained until discharge.
- Rehospitalization data showed lower diagnostic stability (71.3%) and highlighted mood and schizophrenia spectrum disorders as more consistent, whereas many other diagnoses were less stable with associations noted between hospitalization length, age, and diagnostic changes.
Article Synopsis
- Hyperprolactinemia and metabolic issues are common side effects of antipsychotics, leading to treatment intolerance, yet there are no solid guidelines for switching medications in these cases.
- The study analyzed 177 patients with hyperprolactinemia from amisulpride and 274 with metabolic disturbances from olanzapine, finding that higher baseline PANSS scores indicated a greater likelihood of relapse after switching medications.
- Switching to aripiprazole was associated with an increased risk of relapse while providing benefits like reduced prolactin levels for amisulpride users; however, it did not help in reducing weight or blood sugar levels for those on olanzapine.