Estimating alcoholic prevalence.

Alternative methods for estimating the prevalence of alcoholism and alcohol problems are reviewed and evaluated. No standard method has emerged to fill the void left by the Jellinek formula, now generally recognized as invalid. Currently viable methods include techniques based on alcohol mortality data, alcohol consumption data, data from general population surveys, and data on clients in treatment.

Validity of synthetic estimates of problem-drinker prevalence.

For the purpose of evaluating their validity, survey-based synthetic estimates of problem-drinker prevalence in California's counties were correlated with social indicators of alcohol abuse. Prevalence estimates were predictive of automobile accidents and drunk-driving arrests but not of other problems. Data on drinking practices from a statewide survey provide more valid estimates than national survey data.

The isolation, identification and synthesis of two metabolites of guanethidine formed in pig and rabbit liver homogenates.

1. Two metabolites of radioactively labelled guanethidine were isolated from rabbit and pig liver homogenates by ion-exchange chromatography on a sulphonic acid resin. 2.