Towards a Systemic Concept of the Brain Ishemia Stroke: Monte Carlo Driven Model.

Background: The work proposes a new mathematical model of dynamic processes of a typical spatially heterogeneous biological system, and sets and solves a mathematical problem of modeling the dynamics of the system of neurovascular units of the brain in conditions of ischemic stroke. There is a description of only a small number of mathematical models of stroke in the literature. This model is being studied and a numerical and software implementation of the corresponding mathematical problem is proposed.

Anti-cancer activity of ultra-short single-stranded polydeoxyribonucleotides.

One of the features that differentiate cancer cells is their increased proliferation rate, which creates an opportunity for general anti-tumor therapy directed against the elevated activity of replicative apparatus in tumor cells. Besides DNA synthesis, successful genome replication requires the reparation of the newly synthesized DNA. Malfunctions in reparation can cause fatal injuries in the genome and cell death.

Hybrid Refractive-Diffractive Lens with Reduced Chromatic and Geometric Aberrations and Learned Image Reconstruction.

In this paper, we present a hybrid refractive-diffractive lens that, when paired with a deep neural network-based image reconstruction, produces high-quality, real-world images with minimal artifacts, reaching a PSNR of 28 dB on the test set. Our diffractive element compensates for the off-axis aberrations of a single refractive element and has reduced chromatic aberrations across the visible light spectrum. We also describe our training set augmentation and novel quality criteria called "false edge level" (FEL), which validates that the neural network produces visually appealing images without artifacts under a wide range of ISO and exposure settings.

[The clinical picture of ischemic heart disease following a myocardial infarct].

The course of ischemic heart disease was studied in 167 patients who had survived myocardial infarction (MI). The chief factors determining the course of the disease and prognosis after MI are the degree and number of affected coronary arteries, MI localization, functional state of myocardium and early onset of postinfarction stenocardia.

[Study of CAT gene expression in Sa and pC194 plasmids in Escherichia coli, Francisella tularensis, and Bacillus subtilis cells].

The unit activities were defined for chloramphenicol-acetyltransferases coded for by the cat-genes of the plasmids Sa and pC194 in Francisella tularensis, Escherichia coli and Bacillus subtilis cells. Francisella tularensis cells were shown to hold intermediate position between Escherichia coli and Bacillus subtilis cells in their ability to express the genes of the different taxonomic origin. The direct dependence was found between the dose of the gene coding for chloramphenicol-acetyltransferase synthesis and efficiency of the gene expression, minimal inhibiting concentration of the antibiotic and colony size on the media containing chloramphenicol.