Metformin, Diabetes, and Survival among U.S. Veterans with Colorectal Cancer.

Background: Metformin has been associated with improved colorectal cancer survival, but investigations are limited by small numbers of patients and confounding by diabetic severity. We examined the association between metformin use and overall survival (OS) in patients with diabetes and colorectal cancer in a large population of U.S.

Diabetes, metformin use, and colorectal cancer survival in postmenopausal women.

Background: Observational studies have associated metformin use with lower colorectal cancer (CRC) incidence but few studies have examined metformin's influence on CRC survival. We examined the relationships among metformin use, diabetes, and survival in postmenopausal women with CRC in the Women's Health Initiative (WHI) clinical trials and observational study.

Methods: 2066 postmenopausal women with CRC were followed for a median of 4.