A new quinolone and acetylcholinesterase inhibitors from a sponge-associated fungus sp. SCSIO41033.

The chemical investigation of the EtOAc extract from the solid rice medium cultured with a sponge-associated fungus sp. SCSIO41033 led to the isolation of two quinolones including a new one, penicinolone (), three xanthone derivatives (), and four anthraquinones (). Their structures were determined by comprehensive analysis of H and C NMR, COSY, HSQC, and HMBC spectroscopic, and HRESIMS mass spectrometric data.

Optimized extraction process and identification of antibacterial substances from Rhubarb against aquatic pathogenic .

Response surface optimization was applied for the extraction of antibacterial substances from Rhubarb (ASR) against aquatic pathogenic . Based on the experimental results of single factors, the optimal extraction conditions were determined by Box-Behnken design combined with response surface methodology with conditions: 100% ethanol as extraction solvent, liquid/material ratio of 29 mL/g and extraction temperature at 88 °C for 148 min. The factual value of inhibition zones can reach 21.

Tetramic acid derivatives and polyphenols from sponge-derived fungus and their biological evaluation.

Fifteen compounds, including two tetramic acid derivatives, penicillenol A1 (1) and penicillenol A2 (2), six polyphenols containing both phenolic bisabolane sesquiterpenoid and diphenyl ether units, expansols A-F (3-8), together with six phenolic bisabolane sesquiterpenoids (9-14) and diorcinol (15), were isolated from the fermentation broth of the marine-derived fungus ZSDS1-F11 isolated from the sponge Phakellia fusca Thiele collected in the Yongxing island of Xisha. Their structures were elucidated mainly by using extensive NMR spectroscopic and mass spectrometric analyses. Compounds 3-5, 7 and 8 showed potent COX-1 inhibitory activity with IC50 values of 5.

A new naphthalene glycoside from the sponge-derived fungus Arthrinium sp. ZSDS1-F3.

One new naphthalene derivative, 1,8-dihydroxynaphthol-1-O-α-l-rhamnopyranoside (1), together with one known α-dibenzopyrone, alternariol (2), and five xanthones (3-7) were isolated from the sponge-derived fungus Arthrinium sp. ZSDS1-F3. All the isolated compounds (1-7) were established by comprehensive analysis of the spectral data, especially 1D and 2D NMR (HMQC and HMBC) spectra.

Steroidal saponins from Lysimachia Paridiformis.

A new steroidal saponin, paridiformoside B (1), was obtained from the EtOH extract of the whole plant of Lysimachia Paridiformis Franch, togerher with one steroidal sapogenin (7) and seven known steroidal saponins (2-6, 8-9). Their structures were elucidated using extensive spectroscopic techniques including 1D and 2D NMR spectra.