Axonal fasciculation and the role of polysialic acid-neural cell adhesion molecule in rat cortical neurons.

Axonal fasciculation is a mechanism deployed by growing axons to reach their targets during development of the nervous system. Published data have suggested the involvement of neuronal cell adhesion molecules (NCAM) in axonal fasciculation. We have characterized the formation of axonal fascicles in serum-free, primary cultures of cortical neurons from embryonic rat brains.

An instance of reduced center of mass displacement: the Ba Gua Zhang walking gait.

The Ba Gua Zhang walking gait was examined in an accomplished practitioner to test the hypothesis that reducing the vertical oscillation of the body center of mass (CoM) conserves energy. Compared to typical walking, center-of-mass displacement and peak vertical ground reaction force decreased during Ba Gua Zhang walking. Muscle activity in the lower extremities and lower back, however, increased.

Alterations in metabolism and gap junction expression may determine the role of astrocytes as "good samaritans" or executioners.

Our knowledge of astroglia and their physiological and pathophysiological role(s) in the central nervous system (CNS) has grown during the past decade, revealing a complex picture. It is becoming increasingly clear that glia play a significant role in the homeostasis and function of the CNS and that neurons should no longer be considered the only cell type that responds, both rapidly and slowly, to electrochemical activity. We discuss recent advances in the field with an emphasis on the impact of hypoxia and ischemia on astrocytic metabolism and the functional relationship between glucose metabolism and gap junctions in astrocytes.

Atypical neuroleptics stimulate neurogenesis in adult rat brain.

Schizophrenia has been treated effectively with atypical neuroleptics without serious side effects. We have shown previously that long-term treatment with atypical neuroleptics is correlated with an improvement of cognition in adult rats. We report here that atypical neuroleptics stimulate a 2- to 3-fold increase in newly divided cells in the subventricular zone in the rat and that some of these new cells in the subventricular zone and hippocampus also express a neuronal marker.