Publications by authors named "Funanani Takalani"
Article Synopsis
- The research focused on using Eudragit S100 and sodium alginate as carriers for tenofovir disoproxil fumarate in the female genital tract, evaluating their effectiveness in drug delivery.
- The study produced nanoparticles using specific methods, confirmed their stable and favorable interactions through various analyses, and demonstrated that the optimal formulation could release 72% of the drug over 96 hours.
- Cytotoxicity tests showed that the TDF-loaded nanoparticles were safe for vaginal epithelial cells, suggesting their potential for long-term use as a microbicide for HIV patients.
Mortality rate of patients infected with HIV-1 has been significantly reduced by using HAART. However, the virus to date has not been eradicated. Transmission of HIV-1 infection through sexual intercourse remains an ongoing challenge, with increased risk of infection occurring in women.
View Article and Find Full Text PDFWomen constitute more than 50% out of millions of individuals infected with HIV-1, the major causative agent of acquired immune deficiency syndrome. About 40% of HIV-1 infections have been reported to initiate in the female reproductive tract. However, the mechanisms through which these infections are spread are poorly understood; hence, there is now a major concern in women who use long acting injectable hormonal contraceptives, particularly Depo-Provera and an increase of HIV-1 risk acquisition.
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