Publications by authors named "Fumiyoshi Hara"
J Biol Chem
September 2021
Article Synopsis
- - The mammalian cytochrome c oxidase (CcO) operates through a bimetallic site involving Fe and Cu, facilitating the reduction of oxygen to water and producing intermediate forms (A-, P-, F-, O-, E-, and R-forms) driven by single-electron donations and proton pumping.
- - X-ray crystallographic analysis at about 1.8 Å resolution of CcO crystals treated with oxygen revealed that the samples predominantly contained the O-form, E-form, and an A-form structure, with significant structural characteristics indicative of high electron affinities and irreversible transitions.
- - The study indicates that the water channel within the H-pathway is closed in the O- and E-forms, and
