P2Y Signaling in Muscle Satellite Cells Contributes to Masseter Muscle Contraction-induced Pain.

The mechanism behind masseter muscle pain, a major symptom of temporomandibular disorder (TMD), has remained poorly understood. Previous report indicates that adenosine triphosphate (ATP) in involved in the masseter muscle pain development, but the role of its hydrolysis product, adenosine diphosphate (ADP), remains uncertain. Consequently, this study aimed to elucidate the ADP role derived from the sustained masseter muscle contraction in the masseter muscle pain development.