A simple model of cortical culture growth: burst property dependence on network composition and activity.

This paper describes large-scale simulations of growth, network formation, and behavior in cultures of dissociated cortical cells. A neuron model that incorporates synaptic facilitation/depression and neurite outgrowth/retraction was used to construct virtual cultures of 10,000 cells whose spiking behavior and evolution were investigated in closed-loop simulations. This approach allows us to perform detailed analysis of the effects of model parameters on burst shape and timing, their changes, and the interrelationship among these behaviors, gross network structure, and model parameters.

Role of linkers in tertiary amines that mediate or catalyze 1,3,5-triazine-based amide-forming reactions.

We studied 1,3,5-triazine-based amide-forming reactions that are mediated or catalyzed by various tert-amines. The representative tert-amine was trimethylamine, which has amido, 1,2,3-triazolyl, aryl, and alkyl linkers. It was found that electron-deficient aryl and heteroaryl linkers, particularly 1,2,3-triazolyl linkers, are superior.