Characteristics of individuals who developed type 2 diabetes from prediabetes despite undergoing interventions, and evaluation of the performance of urinary myo-inositol as a risk factor for developing diabetes.

Aims/introduction: The aim of this study was to clarify the characteristics of individuals with prediabetes who developed type 2 diabetes despite undergoing interventions, and to evaluate the performance of urinary myo-inositol (UMI) as a noninvasive indicator for the risk of developing diabetes.

Materials And Methods: A total of 51 individuals with prediabetes who underwent a 75-g oral glucose tolerance test, ΔUMI (the difference in the UMI : creatinine ratio between before and 120 min after 75-g glucose loading), fasting plasma glucose, insulin, hemoglobin A1c, noninvasive testing (age, body mass index, blood pressure) and general blood tests were measured at baseline, and underwent dietary/exercise guidance for 8 years were studied.

Results: A total of 31 participants developed diabetes in 8 years.

Simple and non-invasive screening method for diabetes based on myoinositol levels in urine samples collected at home.

Objective: To establish a simple screening method for diabetes based on myoinositol (MI) in urine samples collected at home.

Research Design And Methods: Initially, we evaluated the stability of urinary MI (UMI) at room temperature (RT; 25°C) and 37°C in 10 outpatients with type 2 diabetes. We then enrolled 115 volunteers without a current or history of diabetes.

Professional dietary coaching within a group chat using a smartphone application for weight loss: a randomized controlled trial.

Purpose: To test the effectiveness of professional dietary coaching via group chat using a smartphone application (app) for weight loss.

Methods: This study was a 12-week, assessor-blind, parallel-group, waitlist-controlled randomized trial that included a 4-week follow-up period (trial registration, UMIN000025340). Data were collected between October 2016 and May 2017 and were analyzed between July 2017 and January 2018.

A study of urinary myo-inositol as a sensitive marker of glucose intolerance.

Background: We assessed the possibility of using myo-inositol as a marker of glucose intolerance.

Methods: We measured urinary myo-inositol enzymatically before and 2 h after a 75-g oral glucose tolerance test in 564 volunteers, who were divided into four groups [normal glucose tolerance (NGT), impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and diabetes mellitus (DM)]. Furthermore, we classified NGT into NGT-A (2-h blood glucose <120 mg/dl and 2-h glucosuria <50 mg/dl) and NGT-B (remaining NGT subjects).

Determination of urinary myo-inositol concentration by an improved enzymatic cycling method using myo-inositol dehydrogenase from Flavobacterium sp.

Background: To determine myo-inositol more accurately, we improved the enzymatic cycling method.

Methods: We screened myo-inositol dehydrogenase (MIDH; EC.1.