Publications by authors named "Fumio Shoji"
Appl Environ Microbiol
May 2019
Article Synopsis
- The cell wall integrity signaling (CWIS) pathway is essential for fungal cell wall formation and involves key components like sensor proteins, protein kinase C (PKC), and the MAPK pathway.
- Deficiencies in PKC, such as PkcA in certain fungi, are lethal, indicating that targeting PKC could lead to new antifungal treatments.
- A study identified Z-705 as a selective inhibitor of filamentous fungal PKC through screening approximately 800,000 compounds, showing its effectiveness in inhibiting PKC activity and affecting melanin production in response to cell wall stress.
