DT-SCNN: dual-threshold spiking convolutional neural network with fewer operations and memory access for edge applications.

The spiking convolutional neural network (SCNN) is a kind of spiking neural network (SNN) with high accuracy for visual tasks and power efficiency on neuromorphic hardware, which is attractive for edge applications. However, it is challenging to implement SCNNs on resource-constrained edge devices because of the large number of convolutional operations and membrane potential (Vm) storage needed. Previous works have focused on timestep reduction, network pruning, and network quantization to realize SCNN implementation on edge devices.

Rectal cancer-derived exosomes activate the nuclear factor kappa B pathway and lung fibroblasts by delivering integrin beta-1.

Numerous studies have revealed the importance of tumor-derived exosomes in rectal cancer (RC). This study aims to explore the influence of tumor-derived exosomal integrin beta-1 (ITGB1) on lung fibroblasts in RC along with underlying mechanisms. Exosome morphology was observed using a transmission electron microscope.

Breviscapine regulates the proliferation, migration, invasion, and apoptosis of colorectal cancer cells via the PI3K/AKT pathway.

Colorectal cancer (CRC) is ranked as one of the most common malignancies with a high death rate. It has been discovered that breviscapine can alter the progression and development of various cancers. Nevertheless, the function and mechanisms of breviscapine in CRC progression have not yet been described.

Development and validation of postoperative circulating tumor DNA combined with clinicopathological risk factors for recurrence prediction in patients with stage I-III colorectal cancer.

Background: Circulating tumor DNA (ctDNA) detection following curative-intent surgery could directly reflect the presence of minimal residual disease, the ultimate cause of clinical recurrence. However, ctDNA is not postoperatively detected in ≥ 50% of patients with stage I-III colorectal cancer (CRC) who ultimately recur. Herein we sought to improve recurrence risk prediction by combining ctDNA with clinicopathological risk factors in stage I-III CRC.

Surgical treatment of massive stoma site tumors after a curative operation for rectal cancer.

Objective: This study aimed to evaluate the clinical and oncological outcomes of selected rectal cancer patients with massive stoma site tumors who underwent radical resection and reconstruction.

Methods: We reviewed 8 cases of massive stoma site tumors in patients who had permanent gastrointestinal stoma in the abdominal wall following radical resection of rectal cancer between March 2013 and May 2018 at the Peking University Cancer Hospital and Peking University Shougang Hospital.

Results: There were seven males and one female patient, with a median age of 50.

Oncologists' Perspective: When Cancer Encounters COVID-19.

Considering that the course of the COVID‐19 pandemic remains to be seen, this letter to the editor considers that longstanding structural changes that may be required in oncology institutions.

Functional Passenger-Strand miRNAs in Exosomes Derived from Human Colon Cancer Cells and Their Heterogeneous Paracrine Effects.

Exosome-mediated microRNAs (miRNAs) are closely related to the occurrence, development, invasion, metastasis, therapeutic resistance, diagnosis and treatment of malignant tumors. Guide-strand miRNA and passenger-strand miRNA (miRNA*) exist in miRNA processing, but the function of passenger-strand miRNA is often overlooked. In this study, we attempted to identify functional miRNA*s in exosomes derived from human colon cancer SW620 cells.

An enrichment model using regular health examination data for early detection of colorectal cancer.

Objective: Challenges remain in current practices of colorectal cancer (CRC) screening, such as low compliance, low specificities and expensive cost. This study aimed to identify high-risk groups for CRC from the general population using regular health examination data.

Methods: The study population consist of more than 7,000 CRC cases and more than 140,000 controls.

An oncogenic gene, SNRPA1, regulates PIK3R1, VEGFC, MKI67, CDK1 and other genes in colorectal cancer.

Purpose: Colorectal cancer (CRC) caused more than 65,000 mortalities worldwide per year. It is a result of one or a combination of chromosomal instability, CpG island methylator phenotype, and microsatellite instability. SNRPA1 (small nuclear ribonucleoprotein polypeptide A) is a subunit of spliceosome complex that is involved in the RNA processing.

Case-matched study of short-term effects of 3D vs 2D laparoscopic radical resection of rectal cancer.

Background: The purpose of this study is to compare and evaluate the security and efficacy of 3D vs 2D laparoscopy in rectal cancer treatment.

Methods: Forty-six patients who suffered from rectal cancer and went on laparoscopic radical resection of rectal carcinoma in Peking University Shougang Hospital from Feb. 2015 to Mar.

Positive feedback between oncogenic KRAS and HIF-1α confers drug resistance in colorectal cancer.

Approximately 30%-50% of colorectal cancers (CRCs) harbor the somatic mutated KRAS gene. KRAS G12V, one of the most common KRAS mutations in CRCs, is linked to increased tumor aggressiveness, less response to anti-epidermal growth factor receptor (EGFR) therapy, and poor survival rate. In this study, we sought to determine whether resistance to EGFR inhibitors in colorectal cancer cells harboring KRAS G12V mutation is associated with hypoxia.

[Minimally invasive low-collar incision in near total thyroidectomy].

Objective: To explore the clinical feasibility and features of adopting a low-collar arc-shaped incision for minimally invasive near total thyroidectomy.

Methods: From April 1998 to March 2007, the procedure was accepted by 53 patients with thyroidal nodules, including nodular goiter (n = 34), thyroid adenoma (n = 12) and thyroid carcinoma (n = 7). Near total thyroidectomy was performed through a 2 - 4 cm low-collar horizontal skin incision by conventional instrumentation.