Publications by authors named "Fuminari Tatsugami"

Ventricular tachycardia (VT) is a severe arrhythmia commonly treated with implantable cardioverter defibrillators, antiarrhythmic drugs and catheter ablation (CA). Although CA is effective in reducing recurrent VT, its impact on survival remains uncertain, especially in patients with extensive scarring. Stereotactic arrhythmia radioablation (STAR) has emerged as a novel treatment for VT in patients unresponsive to CA, leveraging techniques from stereotactic body radiation therapy used in cancer treatments.

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In this narrative review, we review the applications of artificial intelligence (AI) into clinical magnetic resonance imaging (MRI) exams, with a particular focus on Japan's contributions to this field. In the first part of the review, we introduce the various applications of AI in optimizing different aspects of the MRI process, including scan protocols, patient preparation, image acquisition, image reconstruction, and postprocessing techniques. Additionally, we examine AI's growing influence in clinical decision-making, particularly in areas such as segmentation, radiation therapy planning, and reporting assistance.

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The integration of deep learning (DL) in breast MRI has revolutionized the field of medical imaging, notably enhancing diagnostic accuracy and efficiency. This review discusses the substantial influence of DL technologies across various facets of breast MRI, including image reconstruction, classification, object detection, segmentation, and prediction of clinical outcomes such as response to neoadjuvant chemotherapy and recurrence of breast cancer. Utilizing sophisticated models such as convolutional neural networks, recurrent neural networks, and generative adversarial networks, DL has improved image quality and precision, enabling more accurate differentiation between benign and malignant lesions and providing deeper insights into disease behavior and treatment responses.

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Background: Low-keV virtual monoenergetic images (VMIs) of dual-energy computed tomography (CT) enhances iodine contrast for detecting small arteries like the Adamkiewicz artery (AKA), but image noise can be problematic. Deep-learning image reconstruction (DLIR) effectively reduces noise without sacrificing image quality.

Purpose: To evaluate whether DLIR on low-keV VMIs of dual-energy CT scans improves the visualization of the AKA.

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Article Synopsis
  • Interventional oncology uses image-guided therapies like tumor embolization and ablation to treat malignant tumors minimally invasively, and AI is gaining traction in this field.
  • Recent literature shows a spike in studies exploring AI applications for tasks such as automatic segmentation, treatment simulation, and predicting treatment outcomes, with the latter being the most researched area.
  • Although many AI methods are still in the research phase and not widely used in clinical settings, the rapid advancements indicate that AI technologies will likely be integrated into interventional oncology practices soon.
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  • - This review investigates the role of Large Language Models (LLMs) in nuclear medicine, particularly focusing on imaging techniques like PET and SPECT, highlighting recent advancements in both fields.
  • - It discusses current developments in nuclear medicine and how LLMs are being used in related areas like radiology for tasks such as report generation and image interpretation, with the potential to improve medical practices.
  • - Despite the promise of LLMs, challenges like reliability, explainability, and ethical concerns need to be addressed, making further research essential for integrating these technologies into nuclear medicine effectively.
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  • MRI is crucial for diagnosing pelvic issues related to organs like the prostate, bladder, and uterus, and uses RADS to standardize the process.
  • AI technologies, including machine learning, are being integrated into pelvic MRI to enhance various steps of diagnosis, especially for prostate imaging.
  • Recent multi-center studies highlight how AI can improve the effectiveness and reliability of pelvic MRI diagnostics by making findings more generalizable across different healthcare settings.
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  • * This review examines the environmental challenges associated with AI systems, such as greenhouse gas emissions from data centers and electronic waste, while also proposing solutions like energy-efficient models and renewable energy usage.
  • * It highlights the need for sustainable practices in AI deployment, suggesting policies, collaboration, and eco-friendly approaches, to ensure that AI advancements do not compromise environmental health.
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Purpose: Super-resolution deep-learning-based reconstruction: SR-DLR is a newly developed and clinically available deep-learning-based image reconstruction method that can improve the spatial resolution of CT images. The image quality of the output from non-linear image reconstructions, such as DLR, is known to vary depending on the structure of the object being scanned, and a simple phantom cannot explicitly evaluate the clinical performance of SR-DLR. This study aims to accurately investigate the quality of the images reconstructed by SR-DLR by utilizing a structured phantom that simulates the human anatomy in coronary CT angiography.

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  • Deep Learning (DL) has advanced diagnostic radiology by improving image analysis, and the introduction of Transformer architecture and Large Language Models (LLMs) has further transformed this area.* -
  • LLMs can streamline the radiology workflow, aiding in tasks like report generation and diagnostics, especially when combined with multimodal technology for enhanced applications.* -
  • However, challenges like information inaccuracies and biases remain, and radiologists need to understand these technologies better to maximize their benefits while ensuring medical safety and ethical standards.*
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  • The review discusses how artificial intelligence (AI) enhances radiation therapy by improving tumor segmentation and treatment planning, making processes much faster for oncologists.
  • AI technologies like deep learning and knowledge-based planning can generate treatment plans comparable to human-created ones, and they can aid in quality control and monitoring during treatment.
  • While challenges like data accumulation exist, the future of AI in radiation oncology looks promising, potentially leading to standardized treatments and better outcomes even in resource-limited areas.
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  • The radiopharmaceutical FDG has been a key player in PET scans for over 20 years and is used in various medical fields like oncology and neurology.
  • The integration of AI has improved the accuracy of imaging and diagnosis with FDG-PET, and new radiopharmaceuticals like PSMA and FAPI are being developed.
  • Recent advances in nuclear medicine, including therapies like [Lu]-dotatate, show better results compared to traditional treatments, prompting a review of current evidence and future directions in the field.
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  • AI is a technology that mimics human intelligence and has gained traction over the past decade due to advancements in computing power and big data, particularly in the medical field.
  • The article emphasizes the importance of developing explainable AI for diagnostic imaging, which can aid physicians in making informed decisions while recognizing AI's limitations.
  • The focus of the review is on the application of AI in thoracic diagnostic imaging, such as lesion detection, to enhance the understanding and effectiveness for radiologists and clinicians.
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In this review, we address the issue of fairness in the clinical integration of artificial intelligence (AI) in the medical field. As the clinical adoption of deep learning algorithms, a subfield of AI, progresses, concerns have arisen regarding the impact of AI biases and discrimination on patient health. This review aims to provide a comprehensive overview of concerns associated with AI fairness; discuss strategies to mitigate AI biases; and emphasize the need for cooperation among physicians, AI researchers, AI developers, policymakers, and patients to ensure equitable AI integration.

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  • MRI is widely used in clinical practice for examining head and neck diseases due to its ability to clearly show soft tissue details.
  • Recent advancements in artificial intelligence, especially deep learning techniques like convolutional neural networks, are being explored for enhancing head and neck MRI diagnostics.
  • The review highlights the benefits of these AI methods in image processing and disease assessment, while also addressing their limitations and future challenges in clinical application.
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Recent advances in artificial intelligence (AI) for cardiac computed tomography (CT) have shown great potential in enhancing diagnosis and prognosis prediction in patients with cardiovascular disease. Deep learning, a type of machine learning, has revolutionized radiology by enabling automatic feature extraction and learning from large datasets, particularly in image-based applications. Thus, AI-driven techniques have enabled a faster analysis of cardiac CT examinations than when they are analyzed by humans, while maintaining reproducibility.

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This review outlines the current status and challenges of the clinical applications of artificial intelligence in liver imaging using computed tomography or magnetic resonance imaging based on a topic analysis of PubMed search results using latent Dirichlet allocation. LDA revealed that "segmentation," "hepatocellular carcinoma and radiomics," "metastasis," "fibrosis," and "reconstruction" were current main topic keywords. Automatic liver segmentation technology using deep learning is beginning to assume new clinical significance as part of whole-body composition analysis.

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Purpose: The predictive value of F-sodium fluoride (F-NaF) positron emission tomography (PET) in combination with coronary computed tomography (CT) angiography (CCTA) for future coronary events has attracted interest. We evaluated the potential of F-NaF PET/CT following CCTA to predict major coronary events (MACE) during a 5-year follow-up period.

Methods: Forty patients with coronary atherosclerotic lesions detected on CCTA underwent F-NaF PET/CT examination.

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Fractional flow reserve (FFR) derived off-site by coronary computed tomography angiography (CCTA) (FFR) is obtained by applying the principles of computational fluid dynamics. This study aimed to validate the overall reliability of on-site CCTA-derived FFR based on fluid structure interactions (CT-FFR) and assess its clinical utility compared with FFR, invasive FFR, and resting full-cycle ratio (RFR). We calculated the CT-FFR for 924 coronary vessels in 308 patients who underwent CCTA for clinically suspected coronary artery disease.

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The main purpose of pre-transcatheter aortic valve implantation (TAVI) cardiac computed tomography (CT) for patients with severe aortic stenosis is aortic annulus measurements. However, motion artifacts present a technical challenge because they can reduce the measurement accuracy of the aortic annulus. Therefore, we applied the recently developed second-generation whole-heart motion correction algorithm (SnapShot Freeze 2.

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Article Synopsis
  • Deep learning-based spectral CT imaging (DL-SCTI) enhances image quality by using advanced networks to fill in missing data and improve visual accuracy for dual-energy scans.
  • A clinical study involving 52 patients with hypervascular hepatocellular carcinoma (HCC) found that DL-SCTI-generated iodine maps significantly improved the contrast-to-noise ratio (CNR) during the hepatic arterial phase compared to standard 70 keV images.
  • While DL-SCTI effectively detects HCCs, it may underestimate iodine concentration in small lesions or lower concentrations, indicating limitations in certain scenarios.
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  • The study aimed to compare the image quality of coronary CT angiography using two different reconstruction methods: super-resolution deep learning reconstruction (SR-DLR) and hybrid iterative reconstruction (IR).
  • It involved 100 patients and measured factors like image noise, contrast-to-noise ratio (CNR), and plaque detectability using a scoring system.
  • Results showed that SR-DLR provided significantly lower image noise, higher CNR, sharper edges, and better plaque detection compared to hybrid IR, demonstrating its superiority in image quality.
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  • * Computed tomography (CT) plays a crucial role in diagnosing bowel ischemia and identifying its causes, which include small bowel obstruction and various forms of mesenteric ischemia.
  • * Understanding the CT findings and their clinical significance is essential for making informed treatment decisions based on the specific underlying mechanisms of bowel ischemia.
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The evidence for the clinical implications, especially the short-term utility, of native myocardial T1 value (T1) on cardiac magnetic resonance (CMR) in nonischemic dilated cardiomyopathy (NIDCM) is scant. We investigated the potential of T1 to assess left ventricular (LV) myocardial characteristics and predict 1-year outcomes in patient with NIDCM experiencing recent heart failure (HF).Forty-five patients with NIDCM and HF symptoms within 3 months underwent CMR with cine, non-contrast T1 mapping, and late gadolinium enhancement (LGE).

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Purpose: How coronary arterial F-sodium fluoride (F-NaF) uptake on positron emission tomography changes over the long term and what clinical factors impact the changes remain unclear. We sought to investigate the topics in this study.

Methods: We retrospectively studied 15 patients with ≥1 coronary atherosclerotic lesion/s detected on cardiac computed tomography who underwent baseline and follow-up (interval of >3 years) F-NaF positron emission tomography/computed tomography scans.

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