Corrigendum: Structures and biological activities of novel 4'-acetylated analogs of chrysomycins A and B.

This corrects the article DOI: 10.1038/ja.2017.

Structures and biological activities of novel 4'-acetylated analogs of chrysomycins A and B.

Two new 4'-acetylated analogs of chrysomycin were discovered during the screening for antitumor agents from the metabolites of actinomycetes. Their structures and physicochemical properties were determined by standard spectrometric analyses. Their cytotoxicities and antimicrobial activities were evaluated against a panel of cancer cell lines and microbes.

Stability and Bioavailability of Lentztrehaloses A, B, and C as Replacements for Trehalose.

Trehalose is widely used as a sweetener, humectant, and stabilizer, but is ubiquitously degraded by the enzyme trehalase expressed in a broad variety of organisms. The stability of the new trehalose analogues lentztrehaloses A, B, and C in microbial and mammalian cell cultures and their pharmacokinetics in mice were analyzed to evaluate their potential as successors of trehalose. Among the 12 species of microbes and 2 cancer cell lines tested, 7 digested trehalose, whereas no definitive digestion of the lentztrehaloses was observed in any of them.