Publications by authors named "Fumikazu Koyama"
Malassezia species are lipophilic yeasts recognized for causing skin manifestations, such as pityriasis versicolor. In addition, Malassezia can lead to invasive infection, mostly intravascular catheter-associated sepsis-related lipid-containing total parenteral nutrition in neonates and immunocompromised hosts. We experienced a case of invasive pulmonary Malassezia infection in a patient with refractory ulcerative colitis undergoing immunosuppressive treatment without lipid-containing total parenteral nutrition.
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- The study explored how the COVID-19 pandemic affected the diagnosis and treatment of colorectal cancer (CRC) by comparing patient data before and during the pandemic.* -
- Findings showed a significant decrease in positive fecal occult blood tests and patients took longer to seek medical help for symptoms during the pandemic, even though the stage of cancer remained unchanged.* -
- Despite patients being hesitant to seek treatment, healthcare practitioners' behavior stayed consistent, resulting in no significant differences in overall survival or recurrence-free survival rates.*
Article Synopsis
- The study investigates the differences in histological features between colitis-associated intestinal cancer (CAC) and sporadic colorectal cancer (CRC) in patients with inflammatory bowel disease.
- Data from a national database in Japan covering over 36 years was used to analyze 1,077 cases of ulcerative colitis-related CAC and 297 cases related to Crohn’s disease, alongside a large cohort of sporadic CRC patients.
- Findings reveal that CAC exhibits a higher prevalence of aggressive cancer types compared to sporadic CRC, with this difference becoming more prominent as the tumors progress.
A proposed new Japanese classification of synchronous peritoneal metastases from colorectal cancer: A multi-institutional, prospective, observational study conducted by the Japanese Society for Cancer of the Colon and Rectum.
Ann Gastroenterol Surg
September 2023
Aim: To establish a new Japanese classification of synchronous peritoneal metastases from colorectal cancer.
Methods: This multi-institutional, prospective, observational study enrolled patients who underwent surgery for colorectal cancer with synchronous peritoneal metastases. Overall survival rates were compared according to the various models using objective indicators.
Article Synopsis
- A study evaluated postoperative anastomotic lesions in Crohn's disease (CD) patients who underwent intestinal resection, finding that these lesions commonly recur within a year.
- Researchers analyzed data from 267 patients and noted that the severity and prevalence of these lesions increased over time, leading to more interventions for those with more severe lesions.
- The findings suggest that intermediate and severe lesions might indicate recurrent disease, while mild lesions may not, highlighting the need for further prospective studies to improve treatment approaches.
Article Synopsis
- Colorectal cancer (CRC) presents a significant risk for patients with Crohn's disease (CD), and this study aimed to investigate the prognosis and characteristics of CD-related CRC (CD-CRC) compared to sporadic CRC using a large database of cases.
- The analysis included 233 CD-CRC patients and 129,783 sporadic CRC patients, revealing that CD-CRC patients were typically younger, more likely to have rectal cancer, multiple tumors, and a distinct type of cancer called mucinous adenocarcinoma, all resulting in lower survival rates.
- The findings showed a lower five-year overall survival rate for CD-CRC (53.99% vs. 71.17% for sporadic CRC
A tailgut cyst is a rare, developmental cyst occurring in the presacral space. Although primarily benign, malignant transformation is a possible complication. Herein, we report a case of liver metastases after resection of a neuroendocrine tumor (NET) arising from a tailgut cyst.
View Article and Find Full Text PDFIntroduction: The aim of this study was to evaluate the effect of biologics on the risk of advanced-stage inflammatory bowel disease (IBD)-associated intestinal cancer from a nationwide multicenter data set.
Methods: The medical records of patients with Crohn's disease (CD) and ulcerative colitis (UC) diagnosed with IBD-associated intestinal neoplasia (dysplasia or cancer) from 1983 to 2020 were included in this study. Therapeutic agents were classified into 3 types: biologics, 5-aminosalicylic acid, and immunomodulators.
Background: Patients with longstanding inflammatory bowel disease are at high risk of developing intestinal cancers. In this study, we aimed to elucidate the differences between intestinal cancers associated with ulcerative colitis and Crohn's disease.
Methods: Intestinal cancers in ulcerative colitis and Crohn's disease patients treated between 1983 and 2020 at 43 Japanese institutions were retrospectively analyzed.
Cronkhite-Canada syndrome (CCS) is a non-hereditary disorder characterized by non-neoplastic gastrointestinal polyposis and ectodermal changes. While corticosteroids are considered effective, some cases are refractory. A 48-year-old woman presented with diarrhea, anorexia, and epigastralgia lasting for 3 months.
View Article and Find Full Text PDFA 70-year-old man underwent surveillance colonoscopy following surgery for occlusive sigmoid colon cancer. The procedure revealed nine sessile serrated lesions (SSLs), including three inverted lesions. Endoscopic and surgical resections were performed.
View Article and Find Full Text PDFBackground: The novel 2019 coronavirus disease (COVID-19), which is caused by infection with the severe acute respiratory syndrome coronavirus 2, has spread rapidly around the world and has caused many deaths. COVID-19 involves a systemic hypercoagulable state and arterial/venous thrombosis which induces unfavorable prognosis. Herein, we present a first case in East Asia where an acute superior mesenteric artery (SMA) occlusion associated with COVID-19 pneumonia was successfully treated by surgical intervention.
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- The study investigates the characteristics of tumor cells that are exfoliated during colorectal endoscopic submucosal dissection (ESD) and their potential to cause local recurrence.
- Researchers collected samples from 19 patients post-ESD and analyzed gene mutations in both primary tumors and exfoliated cells, finding high concordance in mutations.
- Results indicated that while these exfoliated cells had survival-promoting mutations and remained viable for extended periods, treatment with a 2.0% povidone-iodine solution effectively reduced their viability.
A Ventral Hernia-repair-related Mesh Infection Treated with NPWT without Mesh Removal.
Plast Reconstr Surg Glob Open
September 2021
Article Synopsis
- Abdominal hernia repairs often use prosthetic mesh, which can get infected, typically requiring mesh removal, but recent cases show that negative-pressure wound therapy (NPWT) might save infected mesh.
- An 85-year-old woman's ventral hernia repair resulted in a rare nontuberculous mycobacterium infection, leading to pus discharge and necrosis under the mesh by the seventh day after surgery.
- After 4 weeks of NPWT, the infection showed improvement and good tissue healing, suggesting that NPWT could be a viable option to preserve infected mesh when guided by an infectious disease specialist.
Purpose: To evaluate the effect of mild renal dysfunction on the clinical course after colectomy in patients with colon cancer.
Methods: The subjects of this retrospective study were 263 patients who underwent surgical resection for colon cancer at our hospital between 2011 and 2015. Renal function was assessed based on preoperative estimated glomerular filtration rate (eGFR) values.
Article Synopsis
- Genetic analysis uncovered a variant of unknown significance, prompting further investigation through reverse transcription-PCR, which revealed complex splicing abnormalities.
- After two years, the previously uncertain mutation was reclassified as "likely pathogenic," highlighting reverse transcription-PCR's potential in identifying significant genetic variants in cases with undetectable mismatch repair proteins by IHC.
Objectives: Many patients have endoscopic evidence of recurrent Crohn's disease (CD) 1 year after intestinal resection, and endoscopic lesions predict future clinical recurrence. The aim of this study was to describe some anastomotic lesions including changes in endoscopic features in CD patients and to discuss recurrence. We also compared anastomotic lesions in CD patients and in right-side colon cancer (rt-CC) patients.
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- Lateral lymph node (LLN) metastasis is a major cause of local recurrence in lower rectal cancer, and current methods can't predict it before surgery.
- A study reviewed data from 102 patients who underwent surgery and imaging to find a relationship between the middle rectal artery (MRA) and LLN metastasis, with notable findings by two expert radiologists.
- The study found that the presence of MRA is a strong predictor of LLN metastasis, with high sensitivity and negative predictive value, suggesting it can help guide treatment strategies for affected patients.
Purpose: Primary tumor location of colon cancer has been reported to affect the prognosis after curative resection. However, some reports suggested the impact was varied by tumor stage. This study analyzed the prognostic impact of the sidedness of colon cancer in stages II, III, and liver metastasis after curative resection using propensity-matched analysis.
View Article and Find Full Text PDFPurpose: The purpose of this study was to evaluate the effectiveness of a wound closure method using a combination of subcuticular sutures and subcutaneous closed-suction drainage (SS closure) for preventing incisional surgical site infection (SSI) in loop ileostomy closure.
Methods: A total of 178 consecutive patients who underwent loop ileostomy closure at Nara Medical University Hospital between 2004 and 2018 were retrospectively assessed. The patients were divided into 2 groups: the conventional skin closure (CC) group from 2004 to 2009 (75 patients) and the SS closure (SS) group from 2010 to 2018 (103 patients).