Publications by authors named "Fumika N Nagase"
Article Synopsis
- Tocilizumab (TCZ) is an effective treatment for giant cell arteritis (GCA), but its impact on treatment changes and outcomes following relapses or discontinuations due to adverse events (AEs) is not well studied.
- In a retrospective study of 62 GCA patients receiving TCZ, 16% experienced relapses, often after dosage adjustments or stopping TCZ; most relapses were manageable with treatment modifications.
- About 45% of patients experienced AEs, with a small portion discontinuing TCZ; those who used alternative immunosuppressive therapies had better outcomes in managing GCA and avoiding relapses.
Article Synopsis
- Water diuresis complicates the treatment of profound hyponatremia, often appearing within the first 24 hours of therapy alongside shifts in urine characteristics.
- Monitoring urine output and composition during early treatment is crucial for promptly identifying this condition.
- In a study of 47 patients, 64% exhibited water diuresis, primarily due to various causes, with significant changes in urine volume and electrolytes noted shortly after treatment initiation.
Severe hyponatremia can cause life-threatening cerebral edema. Treatment comprises rapid elevation of serum sodium concentration; however, overcorrection can result in osmotic demyelination. This study investigated potential factors, including predictive correction based on the Edelman equation, associated with appropriate correction in 221 patients with a serum sodium concentration ≤ 120 mEq/L who were admitted to a hospital in Nagoya, Japan.
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