Publications by authors named "Fumihiro Yoshimura"
Background: Discontinuity at the site of osteotomy is a complication after periacetabular osteotomy. The objectives of this study were to assess whether discontinuity is owed to delayed union or non-union and to clarify the risk factors associated with discontinuity >1 year after periacetabular osteotomy.
Methods: We performed a retrospective review of 104 hips in 95 consecutive patients who underwent periacetabular osteotomy between 2017 and 2021.
Background Therapeutic drug monitoring (TDM) is an effective approach to improving the efficacy of drugs with a narrow therapeutic index and high toxicity. TDM-guided dosing of 5-fluorouracil (5-FU) has been shown to result in superior efficacy and fewer adverse events compared to body surface area (BSA)-based dosing. Therefore, accurate measurement of plasma 5-FU concentrations after capecitabine administration is necessary.
View Article and Find Full Text PDFArticle Synopsis
- * 117 hips from 104 patients were assessed using CT images one year after surgery to see the incidence of delayed union at the osteotomy sites.
- * Results showed that the group using both imaging views and delayed PWB (OL group) had a significantly lower incidence of delayed union (3.5%) compared to the control group (C group) using only one imaging view and early PWB (22%).
Coronavirus disease 2019 is known to cause severe acute respiratory syndrome, and serious cases need to be treated with corticosteroids. Herein, we report an 87-year-old woman who developed bilateral osteonecrosis of the femoral head after corticosteroid treatment for coronavirus disease 2019-related pneumonia. Sixteen months after treatment, she developed right hip pain without any evidence of trauma.
View Article and Find Full Text PDFBackground: Curved periacetabular osteotomy requires detachment and retraction of the hip flexors. In this study, we evaluated hip flexor muscle status by magnetic resonance imaging (MRI) shortly after curved periacetabular osteotomy.
Methods: We retrospectively evaluated 60 hips of 56 patients by MRI 1 week and 3 months after curved periacetabular osteotomy performed from August 2017 to December 2019.
Article Synopsis
- Endoscopic therapy has significantly advanced, particularly in using suturing techniques within the gastrointestinal tract.
- Current methods mainly rely on closure with instruments or continuous sutures via an endoscopic needle holder, highlighting a lack of effective nodal suturing options involving extracorporeal ligation.
- This paper presents a new endoscopic ligation technique that employs a flexible endoscope for performing nodal suturing through extracorporeal ligation.
Intramedullary nails are an effective treatment for common femoral trochanteric fractures. However, one of their complications is implant breakage due to poor reduction and nonunion after surgery. We herein report a case of a 54-year-old man who underwent total hip arthroplasty for nonunion after internal fixation of a femoral trochanteric fracture.
View Article and Find Full Text PDFArticle Synopsis
- * The GIST measured 12×12 mm and exhibited an intra-luminal growth pattern, prompting the need for surgical intervention.
- * A new technique of full-thickness resection through a submucosal tunnel was used, resulting in a successful R0 resection, indicating no remaining cancerous cells.
Article Synopsis
- The study compared the efficacy of computed tomography (CT) and cardiac magnetic resonance (CMR) in measuring myocardial extracellular volume (ECV) in patients with cardiac amyloidosis (CA).
- Both modalities showed similar mean global ECVs, with strong correlations between CT-ECV and CMR-ECV across various heart segments.
- Findings suggest that CT can effectively serve as a practical alternative to CMR for assessing ECV in a clinical setting, providing valuable insights related to patient status.
Purpose: To evaluate the diagnostic performance of myocardium-to-lumen R1 (1/T1) ratio on postcontrast T1 maps for the detection of cardiac amyloidosis in a large patient sample.
Materials And Methods: This retrospective study included consecutive patients who underwent MRI-derived extracellular volume fraction (MRI ECV) analysis between March 2017 and July 2021 because of known or suspected heart failure or cardiomyopathy. Pre- and postcontrast T1 maps were generated using the modified Look-Locker inversion recovery sequence.
The effect of the AirSeal insufflation system on hemodynamic parameters, especially end-tidal carbon dioxide (EtCO), during laparoscopic abdominal surgery remains unclear. This retrospective single-center study included 333 consecutive patients who underwent laparoscopic hepatectomy (n = 43), gastrectomy (n = 69), colectomy (n = 137), or proctectomy (n = 84) using the AirSeal. Patient demographics and intraoperative hemodynamic parameters, such as EtCO, peripheral capillary oxygen saturation (SpO), and arterial systolic blood pressure (ABP), were collected and analyzed.
View Article and Find Full Text PDFPurpose: To investigate the postoperative quality of life (QOL) in patients with proximal gastric cancer (PGC) or esophago-gastric junction cancer, a nationwide multi-institutional study (PGSAS NEXT trial) was conducted.
Methods: Patients who had undergone radical resection more than 6 months previously were enrolled from 70 Japanese institutions between July 2018 and June 2020. The Postgastrectomy Syndrome Assessment Scale (PGSAS)-45 questionnaire was distributed to eligible patients, and responses were collected by mail.
Article Synopsis
- This study investigates the potential of using circulating tumor DNA (ctDNA) from colorectal cancer patients to predict tumor recurrence, focusing on mutations in the KRAS gene.
- It involved analyzing blood samples from 84 patients with specific KRAS mutations, although no direct link was found between KRAS mutation levels and tumor recurrence.
- The findings indicate correlations between tumor characteristics (like size and stage) and preoperative KRAS mutation levels, but suggest that ctDNA detection for predicting recurrence isn't reliable post-surgery.
Article Synopsis
- Third-space endoscopic techniques like POET and STER allow surgeons to reach deep tissues that were previously hard to access with traditional endoscopes.
- A case of a 29-year-old man with a 40 × 25 mm leiomyoma in his upper thoracic esophagus demonstrated the effectiveness of POET, which involved full-thickness resection while ensuring safety around surrounding structures like the azygos vein.
- Successful use of POET highlights its potential as a groundbreaking technique for removing non-epithelial lesions, emphasizing the need for detailed imaging and careful dissection during procedures.
Article Synopsis
- * Of the 362 patients studied, 11 had the BRAF V600E mutation, and though tumor size was linked to mutant allele frequency (MAF), no direct correlation was found between MAF and recurrence.
- * The research indicates that while MAF increases over time in some patients, using it for early recurrence prediction in colorectal cancer post-surgery remains challenging.
Article Synopsis
- Laparoscopic pancreas-sparing distal duodenectomy is a minimally invasive surgical method for tumors in the duodenum, but it is technically challenging due to the organ's complex anatomy.
- The procedure was successfully performed on two patients with duodenal tumors, involving careful dissection and mobilization, with operative times of 326 and 370 minutes, and they experienced no complications post-surgery.
- This technique is becoming increasingly important as duodenal tumors are being diagnosed more frequently, and the approach proves to be a safe and effective option for excising such tumors without extensive organ mobilization.
Background: The objective of this study was to clarify the onset of arterial and venous thrombosis and the safety of antithrombic therapy in patients with gastrointestinal cancer.
Patients And Methods: In a retrospective cohort study of adults aged ≥ 18 years, 1187 patients with gastrointestinal cancer were admitted to our hospital between January 1, 2015 and December 31, 2017. We investigated the incidence of arterial thromboembolism (ATE) and venous thromboembolism (VTE) and serious bleeding following antithrombotic therapy.
A 54-year-old Japanese woman developed simultaneous abdominal distension and bilateral leg edema. Her medical history and results of periodic medical check-up were unremarkable. Blood tests revealed severe hypoproteinemia and acute kidney injury, and urinalysis revealed 4+ proteinuria and 2+ hematuria.
View Article and Find Full Text PDFBackground/aim: Chemoimmunotherapy is a promising treatment for various malignant diseases. In this study, we examined whether first-line chemoimmunotherapy using adoptive immune-cell therapy was effective for metastatic colorectal cancer (mCRC).
Patients And Methods: The therapeutic efficacy and safety of the standard first-line chemoimmunotherapy with adoptive αβ T cell therapy and bevacizumab were assessed using thirty-two patients with mCRC in our hospital.
In recent years, therapeutic drug monitoring (TDM) of intravenous administration of 5-fluorouracil (5-FU) has resulted in reduced toxicity and improved efficacy. Prodrugs of 5-FU were developed to reduce toxicity, extend the duration of action, and increase tumour selectivity of 5-FU. These drugs are important in daily practice because of their ease of administration.
View Article and Find Full Text PDFIntroduction: Appropriate dissection of the infrapyloric lymph nodes (no. 6 LNs) is important in gastric cancer surgery. In laparoscopic surgery, dissection of the no.
View Article and Find Full Text PDFArticle Synopsis
- Capecitabine is converted to the anticancer drug 5-fluorouracil (5-FU) in tumors by an enzyme called thymidine phosphorylase (TP), and the study looked at how adding a TP inhibitor (5-nitrouracil or 5-NU) affects plasma 5-FU levels.
- After giving capecitabine, blood samples were tested for 5-FU concentrations at different times and conditions, revealing that samples stored at room temperature had significantly higher 5-FU levels compared to those stored at 4°C.
- The presence of 5-NU decreased 5-FU concentrations, with the most significant differences observed at room temperature, suggesting that both storage