Publications by authors named "Fumihiro Hirata"
Background/aim: The aim of the study was to analyze the association between abdominal aortic calcification (AAC) and patient prognosis following resection of colorectal liver metastases (CRLM). AAC potentially reflects intrahepatic immunity and is involved in tumor development and progression. However, the clinical effects of AAC on colorectal cancer (CRC) prognosis after curative-intent liver resection for CRLM remain unclear.
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- The study investigates the variability of anti-tumor effects of natural killer (NK) cells, specifically through a liver immune status index (LISI) that predicts low expression of TRAIL, a protein linked to tumor cell destruction.
- Researchers analyzed liver NK cells from 40 donors and created the LISI using logistic regression to assess its predictive capability in a larger cohort of 586 patients who underwent liver surgery for hepatocellular carcinoma (HCC).
- Findings showed that LISI is a strong independent predictor of cancer recurrence risk, especially in high-risk patients, outperforming other common evaluation indices in those with vascular invasion.
A 70-year-old man presented to our hospital with weight loss. A colonoscopy revealed advanced cancer in the lower rectum. Computed tomography showed a tumor larger than 5 cm in the lower rectum with metastasis to the right lateral lymph node.
View Article and Find Full Text PDFA 56-year-old woman with complaints of anal bleeding and pain visited our hospital, and an elastic soft mass was detected in the anal canal on digital examination.Colonoscopy showed a black Isp polypoid lesion with a black pit from the anal canal to the lower rectum(P-Rb).She was diagnosed with malignant melanoma based on colonoscopic biopsy.
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- The study focused on how chemotherapy affects immune cell function in patients with resectable colorectal cancer that has spread to the liver.
- Two patient groups were analyzed: one receiving adjuvant chemotherapy after liver surgery, and the other undergoing neoadjuvant chemotherapy before surgery, with comparisons made on immune cell characteristics.
- While some immune markers were higher in the neoadjuvant group, their overall immune cell function against cancer cells was similar to the adjuvant group, indicating that neoadjuvant chemotherapy might not harm the immune response in these patients.