Publications by authors named "Fumi Wagai"
Human pluripotent stem cells (hPSCs) dynamically respond to their chemical and physical microenvironment, dictating their behavior. However, conventional in vitro studies predominantly employ plastic culture wares, which offer a simplified representation of the in vivo microenvironment. Emerging evidence underscores the pivotal role of mechanical and topological cues in hPSC differentiation and maintenance.
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- Single-cell RNA sequencing combined with CRISPR allows researchers to understand gene regulation, but single snapshots can miss long-term effects of gene knockouts.
- RENGE is a new computational method that analyzes time-series data from single-cell CRISPR experiments to model how gene knockouts impact regulatory networks over time.
- By distinguishing between direct and indirect gene regulations, RENGE provides more accurate insights into gene interactions, which can help identify important factors in biological systems.