Publications by authors named "Fumi Sakurai"
Article Synopsis
- Fremanezumab is a monoclonal antibody for treating migraines, and a phase 3 study evaluated the safety of self-injection using an autoinjector.
- The study involved 71 migraine patients over 8 weeks and focused on the frequency of treatment-emergent adverse events (TEAEs) during self-injection at home versus at a medical site.
- Results indicated that while at-home injections had more mild injection site reactions, the overall safety profile was reassuring, with significant reductions in migraine days reported.
Streptomyces griseoviridis 2464-S5 produces prodigiosin R1, a tripyrrole antibiotic, and roseophilin, a structurally related compound containing two pyrrole and one furan rings. A gene cluster for the biosynthesis of a prodigiosin was identified in S. griseoviridis.
View Article and Find Full Text PDFRoseophilin is a unique metabolite containing two pyrrole and one furan ring and is structurally related to tripyrrole antibiotics, prodigiosins. Each homologous gene in the roseophilin producer Streptomyces griseoviridis was amplified by PCR using primers designed from the prodigiosin-biosynthesis genes redH, redM, and redW. A search for prodigiosins produced by S.
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