Publications by authors named "Fumei Yin"
A high-quality fluorescence elimination dual-wavelength Raman method for biological detection and its application in cancer diagnosis.
Spectrochim Acta A Mol Biomol Spectrosc
March 2025
Article Synopsis
- Raman-based methods are promising for in vivo biological detection but face challenges due to fluorescence interference in measurement accuracy.
- This study introduces a dual-wavelength Raman method using two different lasers to improve Raman signal quality by eliminating fluorescence effects.
- The method was successfully applied to early cancer diagnosis, identifying significant biomolecules in esophageal tissue that indicate different malignancy levels.
Few studies have provided data on the metabolomics characteristics of metabolic diseases such as hyperuricemia and hyperbilirubinemia in the Tibetan plateau. In the current study, we sought to investigate the serum metabolomics characteristics of hyperbilirubinemia and hyperuricemia in the Tibetan plateau, with the aim to provide a basis for further research on their pathogenesis, prevention, and treatment. The study participants were born in low-altitude areas below 1000 m and had no prior experience living in a high-altitude area before entering Golmud, Tibet (average elevation: 3000 m) and Yushu, Qinghai (average elevation: 4200 m).
View Article and Find Full Text PDFBackground: Gastric cancer is a malignant tumor with high morbidity and mortality. Therefore, the accurate recognition of prognostic molecular markers is the key to improving treatment efficacy and prognosis.
Methods: In this study, we developed a stable and robust signature through a series of processes using machine-learning approaches.
A novel detection technology for early gastric cancer based on Raman spectroscopy.
Spectrochim Acta A Mol Biomol Spectrosc
May 2023
Despite universal endoscopic screening, early detection of gastric cancer is challenging, led researchers to seek for a novel approach in detecting. Raman spectroscopy measurements as a fingerprint of biochemical structure, enable accurate prediction of gastric lesions non-destructively. This study aimed to evaluate the diagnostic power of Raman spectroscopy in early gastric cancer (EGC), and reveal dynamic biomolecular changes in vitro from normal to EGC.
View Article and Find Full Text PDFBackground: Colorectal cancer (CRC), a commonly diagnosed cancer often develops slowly from benign polyps called adenoma to carcinoma. Altered gut microbiota is implicated in colorectal carcinogenesis. It is warranted to find non-invasive progressive microbiota biomarkers that can reflect the dynamic changes of the disease.
View Article and Find Full Text PDFBackground & Aims: The Asia-Pacific Colorectal Screening (APCS) scoring system was developed to stratify the risk of colorectal advanced neoplasm (AN). We aimed to evaluate the performance of the APCS score combined with a stool DNA test used for colorectal cancer screening.
Methods: A total of 2842 subjects who visited outpatient clinics or cancer screening centers were enrolled.