Impact of immune, inflammatory and nutritional indices on outcome in patients with locally advanced cervical cancer treated with definitive (chemo)radiotherapy.

Objective: Systemic immune, inflammatory, and nutritional indices are prognostic across multiple tumor sites. Comprehensive analysis of these markers in patients with locally advanced cervical cancer (LACC) treated with definitive (chemo)radiotherapy [(C)RT] is limited and may assist with future prognostication.

Methods: For this retrospective cohort study, patients with LACC treated with definitive (C)RT were identified from a comprehensive cancer center's clinicopathological database.

AAST multicenter prospective analysis of prehospital tourniquet use for extremity trauma.

Background: Tourniquet use for extremity hemorrhage control has seen a recent increase in civilian usage. Previous retrospective studies demonstrated that tourniquets improve outcomes for major extremity trauma (MET). No prospective study has been conducted to date.

Acadl-SNP based genotyping assay for long-chain acyl-CoA dehydrogenase deficient mice.

The long-chain acyl-CoA dehydrogenase (LCAD) (Acadl=gene; LCAD=protein) deficient mouse model has been important in evaluating the role of mitochondrial fatty acid oxidation of long-chain fatty acids in metabolic disorders. The insertion vector-based gene targeting strategy used to generate this model has made it difficult to distinguish homozygous and heterozygous genotypes containing targeted Acadl alleles in LCAD-deficient mice. Herein, we describe the design and validation of Acadl SNP genotyping methods capable of distinguishing between heterozygous and homozygous LCAD-deficient mice.

Probing eudesmane cation-π interactions in catalysis by aristolochene synthase with non-canonical amino acids.

Stabilization of the reaction intermediate eudesmane cation (3) through interaction with Trp 334 during catalysis by aristolochene synthase from Penicillium roqueforti was investigated by site-directed incorporation of proteinogenic and non-canonical aromatic amino acids. The amount of germacrene A (2) generated by the mutant enzymes served as a measure of the stabilization of 3. 2 is a neutral intermediate, from which 3 is formed during PR-AS catalysis by protonation of the C6,C7 double bond.

First Record of Bacterial Crown Rot of Papaya (Carica papaya) Caused by an Erwinia papayae-Like Bacterium in the Kingdom of Tonga.

Symptoms resembling papaya bacterial crown rot (1,3) attributed to Erwinia papayae were first observed on 'Waimanalo' and 'Solo Sunrise' papaya on the island of Tongatapu, Kingdom of Tonga in July 2009. Spreading, dark green, water-soaked lesions formed on juvenile stem tissue and developed into a foul-smelling, wet rot that destroyed large sections of the stem. Coalescing, brown, angular, marginal, and intercostal lesions killed large areas of the lamina.

Breast cancer patients' clinical outcome measures are associated with Src kinase family member expression.

Background: This study determined mRNA expression levels for Src kinase family (SFK) members in breast tissue specimens and assessed protein expression levels of prominent SFK members in invasive breast cancer to establish associations with clinical outcome. Ki67 was investigated to determine association between SFK members and proliferation.

Methods: The mRNA expression levels were assessed for eight SFK members by quantitative real-time PCR.

First Report of Verticillium Wilt of Gold Kiwifruit, Actinidia chinensis Cv. Hort 16A, Caused by Verticillium albo-atrum in Chile.

Gold kiwifruit, Actinidia chinensis Planch cv. Hort 16A, was first planted in Chile in 2003 and vines started dying within 2 years. By the end of the 2007-2008 growing season, as much as 80% of the plants in several orchards had died.

Multiple gene genealogies and phenotypic characters differentiate several novel species of Mycosphaerella and related anamorphs on banana.

Three species of Mycosphaerella, namely M. eumusae, M. fijiensis, and M.

One hundred US EVAs: a perspective on spacewalks.

In the 36 years between June 1965 and February 2001, the US human space flight program has conducted 100 spacewalks, or extravehicular activities (EVAs), as NASA officially calls them. EVA occurs when astronauts wearing spacesuits travel outside their protective spacecraft to perform tasks in the space vacuum environment. US EVA started with pioneering feasibility tests during the Gemini Program.

Nonenzymatic glycation of human blood platelet proteins.

We studied 11 diabetic patients, all of whom had severe atherothrombotic disease, and 11 normal controls. Overall glycation was assessed by the extent of incorporation of [3H]-NaBH4 into fructosyl lysine separated from whole platelet proteins following aminoacid analysis. Fructosyl lysine represented 5.

Levels of cholesterol, triglyceride, high-density lipoprotein-cholesterol and apoprotein-HDL in an Australian rural population.

Serum levels of total cholesterol, triglyceride, high-density lipoprotein-cholesterol (HDL-C) and apoprotein-HDL (apo-HDL) have been measured in adults of Busselton, Western Australia (males, n = 1600; females, n = 1968) and the distribution of values by age and sex are reported. The data confirm previously reported trends with age for cholesterol and reveal strikingly different ranges and trends with age for triglyceride between males and females, mean values in males increasing more rapidly with age and showing greater variation and more marked positive skew. Mean HDL-C values show little change with age in males, and a slight rise with age in females, up to the 7th decade, and then a fall.

Prevalence of cardiovascular risk factors including fasting serum triglyceride levels in the Cunderdin health survey of 1971.

In a mass health examination conducted in the Shires of Cunderdin and Tammin, 83% of subjects on the electoral rolls attended for screening of cardiovascular risk factors including fasting blood lipid measurements. Fasting serum triglyceride levels are presented. Other factors measured showed quite close similarities to those in the Busselton 1972 Health Survey.