Synthesis, anticancer evaluation, preliminary mechanism study of novel 1, 2, 3-triazole-piperlongumine derivatives.

Piperlongumine, a natural product from traditional Chinese medicine, shows promising antitumor effects but suffers from high toxicity. In this study, X and Q series Piperlongumine derivatives containing 1, 2, 3-triazole were designed and synthesized using the principle of molecular hybridization. The antitumor activity of these target compounds was evaluated, revealing significant activity compared to piperlongumine across four cancer cell lines.

Design, Synthesis and Biological Activity Evaluation of β-Carboline Derivatives Containing Nitrogen Heterocycles.

A series of β-carboline derivatives containing nitrogen heterocycles were designed and synthesized. All compounds were screened for their antitumor activity against four human tumor cell lines (A549, K562, PC-3, T47D). Notably, compound -(4-(morpholinomethyl)phenyl)-2-((5-(1-(3,4,5-trimethoxyphenyl)-9-pyrido[3,4-b]indol-3-yl)-1,3,4-oxadiazol-2-yl)thio)acetamide () exhibited significant inhibitory activity against PC-3 cells with an IC value of 9.

Responses of Soil C, N, P and Enzyme Activities to Biological Soil Crusts in China: A Meta-Analysis.

Biological soil crusts (BSCs) are often referred to as the "living skin" of arid regions worldwide. Yet, the combined impact of BSCs on soil carbon (C), nitrogen (N), phosphorus (P), and enzyme activities remains not fully understood. This study identified, screened and reviewed 71 out of 2856 literature sources to assess the responses of soil C, N, P and enzyme activity to BSCs through a meta-analysis.

Research on Multi-Dimensional Influencing Factors Regarding the Perceived Social Integration of New Urban Immigrants: An HLM Analysis Based on Data from 58 Large- and Medium-Sized Cities in China.

Based on the China Migrants Dynamic Survey (CMDS) data from 2018 and the data from 58 large- and medium-sized cities in China, in this paper a hierarchical linear model was used to investigate the impact of demographic characteristics, social participation, and economic and social development on the perceived social integration of new urban immigrants at the individual and urban levels. The results revealed the following: (1) social participation, gender, age, education, health status, flow time and housing type of new urban immigrants had a significant positive impact on their perceived social integration, while income showed a U-shaped relationship with the sense of urban social integration; (2) macro-urban characteristics regulated the correlation between micro-individual factors and perceived social integration; (3) the significant advantages of new urban immigrants with higher education and more social participation in the process of integration into urban society were more obvious in cities with higher levels of economic development or public services. These findings enriched relevant research on the factors influencing the social integration of new urban immigrants and provided valuable insight with which the government could use to improve urban construction and promote the equalization of basic public services.

Offspring Education and Parents' Health Inequality in China: Evidence from Spillovers of Education Reform.

In the context of a rapidly aging population, improving the parents' health outcomes, especially in parents with poorer health, is essential for narrowing elderly health inequality. Using data from the China Health and Retirement Longitudinal Study, we took the university enrollment expansion policy as the instrumental variable and employed the two-stage least square (2SLS) and instrumental variable quantile regression (IVQR) approaches to explore the spillovers of offspring education on the elderly parents' frailty index. The results show that one additional year of offspring educational attainment was associated with a 0.