Publications by authors named "Fujiyoshi K"
Background: Higher levels of high-sensitivity C-reactive protein (hsCRP) are associated with increased risk of cardiovascular events in patients with coronary artery disease (CAD).
Aims: To elucidate the characteristics of coronary plaques in patients with CAD with high hsCRP levels.
Methods: A total of 793 consecutive patients with stable CAD who underwent optical coherence tomography (OCT) of the culprit vessel during percutaneous coronary intervention were included.
Article Synopsis
- The study investigates the distribution of lymph nodes around the inferior mesenteric artery (IMA) in patients with advanced left-sided colorectal cancer, as complete lymph node dissection is recommended but can lead to complications.
- It involved 30 patients who underwent surgery, where lymph nodes and associated vessels were closely examined, finding that the main lymph nodes were present in 26 patients with varying numbers of nodes dissected.
- The results indicate that most of the main lymph nodes are located near the left colic artery bifurcation, making this area crucial for effective lymph node dissection in advanced cases.
Phosphorylated tyrosine is a fundamental building block of bioactive peptides and proteins. However, the chemoselective phosphorylation of tyrosine over other nucleophilic amino acid residues in unprotected peptides remains a significant challenge. Here we report an umpolung strategy that converts the C-terminal tyrosine into an electrophilic spirolactone cyclohexadienone motif through hypervalent iodine oxidation, followed by a 1,2-phospha-Brook rearrangement using phosphite diesters as nucleophilic phosphoryl donors.
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- This study compared postoperative outcomes for 49 patients with lower rectal cancer who underwent low anterior resection (LAR) or intersphincteric resection (ISR) regarding anal function and quality of life (QOL).
- Key findings showed that while some anorectal manometry results were similar, patients in the ISR group had worse maximum resting pressure and higher fecal incontinence scores compared to the LAR group.
- The research suggests that surgical technique plays a significant role in affecting anal function and fecal incontinence outcomes, but cautions against over-relying on combined assessment methods when evaluating these relationships.
Article Synopsis
- - The study aimed to evaluate the effectiveness of the long cortical bone trajectory (CBT) technique in achieving lumbar spinal fusion and to identify factors that affect the time taken for fusion among patients undergoing this surgery for degenerative spondylolisthesis.
- - A total of 167 patients were analyzed, with results showing a high bone fusion rate of 95.8% by the last follow-up, averaging a fusion time of about 16.6 months post-surgery, but found no significant impact from specific surgical techniques on fusion times.
- - Key independent factors affecting the time to fusion included patient age, sex (females took longer), and BMI, highlighting the importance of these demographic variables over technical procedural choices.
: This is a retrospective case series study. The aim of this study was to investigate whether frailty contributes to functional recovery in individuals with spinal cord injury (SCI). A total of 121 patients with SCI (106 cervical SCI, 15 thoracic SCI) discharged from our center over the past three years were studied.
View Article and Find Full Text PDFBackground/aim: There are no established biomarkers for immune checkpoint inhibitors (ICI) in colorectal cancer (CRC) with microsatellite stability (MSS) or proficient mismatch repair (pMMR). Therefore, this study aimed to identify biomarkers for ICI benefit in patients with pMMR by analyzing the down-regulated DNA repair-related genes involved in highly immunogenic and immune responses, and comparing their expression levels and clinical features.
Materials And Methods: Mismatch repair (MMR), tumor-infiltrating lymphocytes (TIL), and tumor mutation burden (TMB) were evaluated in 13 CRC cases and mRNA expression levels of 95 DNA repair-related genes were measured.
: This study aims to investigate the postoperative improvement of paralysis, fusion rate and risk factors for kyphosis progression in adults affected with spinal caries. : Overall, 134 patients with spinal caries from the thoracic to lumbar spine from 1992 to 2021 were included in this study. Data concerning the affected level (thoracic, thoracolumbar, lumbar, and lumbosacral), bone fusion rate, and progression of the postoperative local kyphosis angle were collected.
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- A study explored whether the COX-2 inhibitor celecoxib, when added to standard chemotherapy, could lower the recurrence risk and improve survival for patients with stage III colon cancer.
- While celecoxib did not show significant benefits for all patients, a subgroup analysis revealed that those with PIK3CA gain-of-function mutations had better disease-free survival (DFS) and overall survival compared to those without these mutations.
- The findings suggest that mutational status, specifically PIK3CA, may help guide the selective use of COX-2 inhibitors along with standard treatment for this type of cancer.
Article Synopsis
- Patients with familial adenomatous polyposis (FAP) face both medical risks and social challenges, particularly related to marriage and childbirth after undergoing colorectal surgery.
- A study of 161 Japanese patients showed that the overall marriage rate post-surgery (57.8%) was similar to that of the general Japanese population, but those unmarried before surgery had a low marriage rate (16.0%).
- Factors like younger age and genetic testing significantly increased the likelihood of getting married post-surgery, and 71% of those who married after surgery went on to have successful pregnancies.
Article Synopsis
- Complete resection of presacral epidermoid cysts is crucial to prevent complications like infection or cancer, but there is no standard surgical method for this procedure.
- A case involving a 44-year-old obese male patient with a large cystic tumor showed successful treatment using a laparoscopic transabdominal resection, offering advantages in visibility and reduced scarring compared to traditional methods.
- The findings suggest that the laparoscopic transabdominal approach is a viable and effective option for removing presacral tumors, especially in obese individuals.
Background: Auscultatory features of heart sounds (HS) in patients with heart failure (HF) have been studied intensively. Recent developments in digital and electrical devices for auscultation provided easy listening chances to recognize peculiar sounds related to diastolic HS such as S or S. This study aimed to quantitatively assess HS by acoustic measures of intensity (dB) and audio frequency (Hz).
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- The study classifies deficient DNA mismatch repair (dMMR) solid tumors into three categories: MLH1-hypermethylated tumors, Lynch syndrome (LS)-associated tumors, and Lynch-like syndrome (LLS)-associated tumors, with varying incidences and unclear pathogenic genes for LLS.
- Researchers analyzed 3,609 tumors from nine different organs, assessing the loss of MMR proteins and performing both methylation and genetic tests, finding that 5.9% of these tumors were dMMR.
- Results indicated that varying tumor types show different incidences of dMMR, with several somatic MMR gene variants identified in LLS tumors, highlighting the need for further studies on LLS genetics for better patient counseling
Background: To achieve good bone fusion in anterior column reconstruction for vertebral fractures, not only bone mineral density (BMD) and bone metabolism markers but also lever arms due to bone bridging between vertebral bodies should be evaluated. However, until now, no lever arm index has been devised. Therefore, we believe that the maximum number of vertebral bodies that are bony and cross-linked with the contiguous adjacent vertebrae (maxVB) can be used as a measure for lever arms.
View Article and Find Full Text PDFPhenological gaps exert a significant influence on the growth of dwarf bamboos. However, how dwarf bamboos respond to and exploit these phenological gaps remain enigmatic. The light environment, soil nutrients, leaf morphology, maximum photosynthetic rate, foliage dynamics, and branching characteristics of were examined under the canopies of and .
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- Patients with familial adenomatous polyposis (FAP) are at a higher risk of gastric neoplasms, including adenomas and cancer, and this study investigates their incidence over time.
- A cohort of 443 FAP patients was analyzed, revealing that by age 50, 22.8% had gastric adenomas and 7.6% had gastric cancer, with the highest risk for adenomas occurring around age 65.
- The study suggests that regular monitoring of the upper gastrointestinal tract in older FAP patients could improve early detection of gastric cancer, indicating a need for more frequent check-ups as patients age.
Background: Spinal cord injury (SCI) causes severe sequelae and significant social loss, depending on the extent of the damage. Most previous studies have focused on the pathology of the spinal cord to develop treatments for SCI. However, it is now known that the brain, which is not directly damaged, also undergoes morphological changes after spinal cord injury, which could affect natural recovery and treatment.
View Article and Find Full Text PDFStudy Design: Retrospective comparative study.
Objective: This study aimed to determine whether the degree of preoperative gait disturbance remains following surgical resection in patients with intradural extramedullary spinal cord tumors (IDEMSCTs), and to investigate any factors that may influence poor improvement in postoperative gait disturbance.
Setting: The single institution in Japan.
Background: The accumulation of advanced glycation end products (AGEs) is associated with cardiovascular events in patients with cardiovascular disease (CVD). However, the relationship between the AGEs measured by an AGEs sensor noninvasively at the fingertip and prognosis in patients with CVD remains unclear. Therefore, this study aimed to determine the relationship between AGEs score and prognosis among patients with CVD.
View Article and Find Full Text PDFBackground/aim: Immunoscore (IS) is an important evaluation method for the tumor immune microenvironment (TIME); however, formal IS analysis requires designated reagents and a specific digital pathology software and image data analysis. This study aimed to investigate whether simplified IS (s-IS) can substitute formal IS upon modifying the location of the assessment of the numbers of immune cells and verify that the addition of T cell subset markers to s-IS can enhance the prognostic impact in patients with colorectal cancer (CRC).
Patients And Methods: A total of 82 CRC cases were included in this study.
Study Design: This study adopted a cross-sectional study design.
Purpose: This study was designed to investigate the effects of bone cross-link bridging on fracture mechanism and surgical outcomes in vertebral fractures using the maximum number of vertebral bodies with bony bridges between adjacent vertebrae without interruption (maxVB).
Overview Of Literature: The complex interplay of bone density and bone bridging in the elderly can complicate vertebral fractures, necessitating a better understanding of fracture mechanics.
Routine tumor-node-metastasis (TNM) staging of colorectal cancer is imperfect in predicting survival due to tumor pathobiological heterogeneity and imprecise assessment of tumor spread. We leveraged Bayesian additive regression trees (BART), a statistical learning technique, to comprehensively analyze patient-specific tumor characteristics for the improvement of prognostic prediction. Of 75 clinicopathologic, immune, microbial, and genomic variables in 815 stage II-III patients within two U.
View Article and Find Full Text PDFIntroduction: Reports on the long-term quality of life (QOL) over 3 years after surgery in patients who have undergone surgery for rectal cancer are limited. Therefore, we aimed to evaluate the long-term QOL of patients who underwent high anterior resection (HAR), low anterior resection (LAR), internal sphincter resection (ISR), or abdominoperineal resection (APR) for rectal cancer.
Methods: A questionnaire regarding QOL was sent to 360 patients with rectal cancer who underwent curative resection by HAR, LAR, ISR, or APR between January 2005 and December 2015.
Background: No study has assessed the incidence or predictors of postoperative shoulder imbalance (PSI) in patients with Lenke type 5C adolescent idiopathic scoliosis (AIS) who underwent selective anterior spinal fusion (ASF). This study evaluated the incidence and predictors of shoulder imbalance after selective ASF for Lenke type 5C AIS.
Methods: In total, 62 patients with Lenke type 5C AIS (4 men and 58 women, mean age at surgery of 15.
Background/aim: The immune system has a pivotal role in modulating the response to chemotherapy in breast cancer (BC). However, the immune status during chemotherapy remains unclear. We evaluated the sequential changes in peripheral systemic immunity markers in BC patients treated with various chemotherapeutic agents.
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