Publications by authors named "Fujino A"
Background: Diabetic kidney disease (DKD) is one of the typical complications of type 2 diabetes (T2D), with approximately 10 % of DKD patients experiencing a Rapid decline (RD) in kidney function. RD leads to an increased risk of poor outcomes such as the need for dialysis. Albuminuria is a known kidney damage biomarker for DKD, yet RD cases do not always show changes in albuminuria, and the exact mechanism of RD remains unclear.
View Article and Find Full Text PDFPurpose: This study aimed to investigate the current practices in the diagnosis and surgical management of anorectal malformations (ARMs) in female patients in Japan, specifically focusing on anovestibular fistula (AVF), rectovaginal fistula (RVF), and persistent cloaca (PC).
Methods: An anonymous online survey was conducted with 61 institutional members of the Japanese Study Group for Anorectal Anomalies.
Results: Sixty-one institutions (100%) completed the survey.
Background: Anticoagulation therapy for atrial fibrillation (AF) has undergone major changes following the introduction of direct oral anticoagulants (DOAC) in 2011. However, the transition of anticoagulation therapy for AF patients with severe renal dysfunction remains to be elucidated.
Methods And Results: Follow-up data, including creatinine clearance (CrCl), were available for 3,706 patients in the Fushimi AF Registry.
Article Synopsis
- A population pharmacokinetic analysis was performed on data from 215 Japanese subjects taking oral sirolimus, identifying factors that affect the drug's pharmacokinetics across different age groups, including neonates, infants, and adults.
- The study found that sirolimus levels increased with higher hemoglobin and that the granule form had significantly higher exposure than the tablet form, while certain drugs decreased its levels significantly.
- The PopPK model developed can help customize sirolimus dosing for individuals based on their age and body weight to ensure effective treatment within the proper concentration range.
Article Synopsis
- - The study explores how NSCLC patients with poor performance status and symptomatic brain metastases can benefit from upfront intracranial treatment, potentially leading to improved overall survival.
- - Data from 50 patients showed that those treated with tyrosine kinase inhibitors (TKI) or immune checkpoint inhibitors (ICI) had better median survival rates (19 months) than those receiving chemotherapy alone (13 months).
- - Results suggest that even patients initially deemed unsuitable for ICI may experience improved survival with personalized treatment approaches, evidenced by significant differences in outcomes based on the type of systemic therapy chosen.
The oral mucosa is the first line of defense against pathogenic bacteria and plays a vital role in maintaining tolerance to food antigens and commensal bacteria. We used CD11c reporter mice to visualize dendritic cells (DCs), a key immune cell population, in the oral cavity. We identified differences in DC density in each oral tissue region.
View Article and Find Full Text PDFArticle Synopsis
- This study examines the diagnosis and treatment practices for rectourethral fistulas (RUF) in male patients with anorectal malformations (ARMs) in Japan, using a comprehensive questionnaire survey among medical institutions.
- Results show that laparoscopic-assisted anorectoplasty (LAARP) is favored for high-type ARMs, while posterior sagittal anorectoplasty (PSARP) is preferred for intermediate-type ARMs, highlighting differences in surgical techniques and tools used.
- The findings indicate distinct management strategies for RUF in PSARP and LAARP procedures, suggesting the need for more research on postoperative outcomes related to these varied approaches.
Background: Type 2 diabetes (T2D) is a significant global health challenge. Physicians need to assess whether future glycemic control will be poor on the current trajectory of usual care and usual-care treatment intensifications so that they can consider taking extra treatment measures to prevent poor outcomes. Predicting poor glycemic control from trends in hemoglobin A (HbA) levels is difficult due to the influence of seasonal fluctuations and other factors.
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- The study aimed to identify factors linked to locomotive syndrome (LS) using medical questionnaires and machine learning techniques.
- A total of 1,575 participants underwent LS risk tests, and after data cleaning, 331 questionnaire items were analyzed to determine their association with LS through advanced statistical methods.
- Nine key factors, especially age and back pain during walking, were identified as strongly correlated with LS, showing better predictive performance compared to existing assessment tools.
Some patients with atrial fibrillation (AF), albeit less frequently, may regress from sustained to paroxysmal type. We sought to investigate how the regression of AF is associated with outcomes. Among the AF patients enrolled in the Fushimi AF Registry who were identified as having sustained AF at baseline, conversion of sustained to paroxysmal AF during follow-up was defined as AF regression.
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- Indocyanine green fluorescence angiography is a noninvasive imaging technique used to evaluate blood flow in tissues, particularly in infants suffering from conditions like necrotizing enterocolitis and midgut volvulus.
- A study reviewed three infant patients who faced complications after surgery, highlighting instances where weak fluorescence indicated areas at risk for ischemia and inadequate blood supply.
- The findings suggest that weak fluorescence can lead to significant postoperative issues, emphasizing the need for careful assessment during surgical procedures to avoid resection of non-viable intestinal segments.
Carotid webs cause ischemic stroke in young people and are associated with a high rate of stroke recurrence. Histopathological examination is crucial for clarifying the pathogenesis and mechanisms underlying the occurrence of carotid webs, although the mechanisms generally remain unclear. Here, we report a case of a symptomatic carotid web in a woman in her 50s who had a medical history of two ischemic strokes.
View Article and Find Full Text PDFAims: Atrial fibrillation (AF) increases the risk of heart failure (HF); however, little is known regarding the risk stratification for incident HF in AF patients, especially with preserved left ventricular ejection fraction (LVEF).
Methods And Results: The Fushimi AF Registry is a community-based prospective survey of AF patients. From the registry, 3002 non-valvular AF patients with preserved LVEF and with the data of antero-posterior left atrial diameter (LAD) at enrolment were investigated.
We developed a simulation model of human oral microbiota using Bio Palette oral medium (BPOM) containing 0.02% glucose and lower bacterial nitrogen sources, derived from saliva and dental plaque. By decreasing the concentration of Gifu anaerobic medium (GAM) from 30 to 10 g L , we observed increased ratios of target pathogenic genera, Porphyromonas and Fusobacterium from 0.
View Article and Find Full Text PDFComparison of Postoperative Respiratory Function Between Patients After Thoracoscopic and Open Lobectomy.
J Laparoendosc Adv Surg Tech A
April 2024
Article Synopsis
- This study compares respiratory function outcomes of patients who underwent thoracoscopic lobectomy (TS) versus those who had thoracotomy (TR) over a 12-year period.
- The TR procedure was found to be quicker and performed on younger patients compared to TS, but both groups showed similar respiratory function results post-surgery after testing at age eight.
- Despite the differences in procedure timing and duration, the pulmonary function test results (forced vital capacity and forced expiratory volume) were not significantly different between the two surgical methods.
Article Synopsis
- Intractable lymphatic anomalies (LAs) include conditions like cystic lymphatic malformations and Gorham-Stout disease, which can cause severe symptoms, necessitating studies on potential treatments.
- A clinical trial conducted in Japan assessed the effectiveness of sirolimus, where 11 patients received daily doses and were monitored for changes in their conditions over 52 weeks.
- Results showed that 54.5% of patients experienced a partial response to treatment, with sirolimus proving to be safe and potentially improving symptoms and quality of life, although no complete responses were achieved.
Article Synopsis
- - This study aimed to evaluate the natural progression of venous malformation (VM) and Klippel-Trenaunay Syndrome (KTS) over a 6-month period by observing changes in lesion volume and other health factors in 34 patients.
- - The results showed no significant overall change in lesion volume or other health metrics such as pain, quality of life, and coagulation markers, but some patients had notable changes linked to local infections.
- - Findings suggest that conducting a Phase 2 study to test new treatments without a placebo is justified, using this data as a standard for comparison.
Article Synopsis
- There is currently no standard diagnostic method or treatment for congenital isolated hypoganglionosis (CIHG), prompting a study to evaluate patient outcomes and surgical interventions over nearly three decades.
- Data from 19 patients were analyzed, focusing on surgical procedures like enterostomy types and the intestinal ratio (IR), with all patients requiring a diverting enterostomy.
- Results indicated that patients with Santulli-type and Bishop-Koop-type stomas had better growth outcomes and lower dependency on parenteral nutrition compared to those with end-stomas or tube-stomas, highlighting the need for tailored surgical approaches and possible intestinal transplantation for achieving enteral autonomy.
Article Synopsis
- The study examines the effect of type 2 diabetes on gingival capillaries in patients with periodontitis, focusing on their structure and density.
- It involved 29 patients, with no significant differences found in periodontal health indicators between those with and without diabetes.
- The findings revealed that while gingival capillary density was similar in both groups, patients with diabetes exhibited a higher rate of morphological abnormalities in their gingival capillaries.
Neonatal omphalitis is a postpartum infection of periumbilical superficial soft tissues that usually has a good prognosis in developed countries. In rare cases, it could progress to periumbilical necrotizing fasciitis (NF), which is an infection of the deep soft tissues, including muscle fascia, and has a high mortality rate. However, the signs and timing of developing NF secondary to omphalitis are unclear.
View Article and Find Full Text PDFBackground: We performed the first autologous oral mucosa-derived epithelial cell sheet transplantation therapy in a patient with refractory postoperative anastomotic stricture in congenital esophageal atresia (CEA) and confirmed its safety. In this study, patients with CEA and congenital esophageal stenosis were newly added as subjects to further evaluate the safety and efficacy of cell sheet transplantation therapy.
Methods: Epithelial cell sheets were prepared from the oral mucosa of the subjects and transplanted into esophageal tears created by endoscopic balloon dilatation (EBD).
Proteinuria is independently associated with heart failure events in patients with atrial fibrillation: the Fushimi AF registry.
Eur Heart J Qual Care Clin Outcomes
December 2023
Aims: Previous studies have shown that proteinuria is independently associated with the incidence of atrial fibrillation (AF), and is also associated with the incidence of cardiovascular events such as stroke and thromboembolism in patients with AF. However, the association of proteinuria with heart failure (HF) events in patients with AF remains unclear.
Methods And Results: The Fushimi AF Registry is a community-based prospective study of patients with AF.