SEP-363856 exerts neuroprotection through the PI3K/AKT/GSK-3β signaling pathway in a dual-hit neurodevelopmental model of schizophrenia-like mice.

Schizophrenia (SZ) is a serious, destructive neurodevelopmental disorder. Antipsychotic medications are the primary therapy approach for this illness, but it's important to pay attention to the adverse effects as well. Clinical studies for SZ are currently in phase ΙΙΙ for SEP-363856 (SEP-856)-a new antipsychotic that doesn't work on dopamine D receptors.

Effect of Boron Doping on the Interlayer Spacing of Graphite.

Boron-doped graphite was prepared by the heat treatment of coke using BC powder as a graphitization catalyst to investigate the effects of the substitutional boron atoms on the interlayer spacing of graphite. Boron atoms can be successfully incorporated into the lattice of graphite by heat treatment, resulting in a reduction in the interlayer spacing of graphite to a value close to that of ideal graphite (0.3354 nm).

Enhanced Thermoelectric Properties of Te Doped Polycrystalline SnPbSe.

Thermoelectric materials can directly convert heat and electricity, which is a kind of promising energy material. In view of cost and mechanical properties, polycrystalline SnSe material with high value is greatly desired. In this study, polycrystalline SnPbSeTe samples were prepared by the vacuum melting-hot pressing sintering method.

Enhanced Thermoelectric Performance of CuSe via Nanostructure and Compositional Gradient.

Forming co-alloying solid solutions has long been considered as an effective strategy for improving thermoelectric performance. Herein, the dense Cu(MnFeNi)Se ( = 0-0.09) with intrinsically low thermal conductivity was prepared by a melting-ball milling-hot pressing process.

Revealing molecular conformation-induced stress at embedded interfaces of organic optoelectronic devices by sum frequency generation spectroscopy.

Interface stresses are pervasive and critical in conventional optoelectronic devices and generally lead to many failures and reliability problems. However, detection of the interface stress embedded in organic optoelectronic devices is a long-standing problem, which causes the unknown relationship between interface stress and organic device stability (one key and unsettled issue for practical applications). In this study, a kind of previously unknown molecular conformation-induced stress is revealed at the organic embedded interface through sum frequency generation (SFG) spectroscopy technique.

Fe-codoped ultra-small NaGdF:Nd nanophosphors: enhanced near-infrared luminescence, reduced particle size and bioimaging applications.

Small-sized lanthanide-doped nanoparticles (NPs) exhibiting superior near-infrared (NIR) luminescence properties are highly desired for bioimaging applications. Herein, Fe ions are codoped in NaGdF:Nd nanocrystals a simple coprecipitation method, which can simultaneously reduce the particle size and enhance the downconverting NIR luminescence of the NPs. The NIR luminescence intensity reaches the maximum for the obtained sub-5 nm NPs when the doping concentration of Fe is tuned to 20 mol%, which is ∼1.

Facile and Scalable Fabrication of CuO Nanoflakes with Excellent Catalytic Properties.

Well dispersed CuO nanoflakes were successfully achieved via a fast and self-heating route. The physical properties of the as-prepared products were analyzed by X-ray powder diffraction (XRD), field emission scanning electron microscopy (FESEM), nitrogen adsorption-desorption measurements, transmission electron microscopy (TEM) and selected area electron diffraction (SAED). Meanwhile, the catalytic activity and the catalytic advantage of CuO nanostructures are discussed with the help of first-order kinetics investigation for methylene blue degradation.

Neodymium-doped NaHoF nanoparticles as near-infrared luminescent/T-weighted MR dual-modal imaging agents in vivo.

The achievement of efficient near-infrared (NIR) luminescence of lanthanide ions in a paramagnetic nanoparticle (NP) host is highly desirable to optimize the performance of multimodal bioprobes. Herein, we present a facile coprecipitation method to prepare highly uniform NaHoF:Nd nanoplates. Upon NIR excitation at 785 nm, efficient NIR luminescence of Nd can be obtained from the paramagnetic NaHoF hosts.

915 nm Light-Triggered Photodynamic Therapy and MR/CT Dual-Modal Imaging of Tumor Based on the Nonstoichiometric Na0.52 YbF3.52 :Er Upconversion Nanoprobes.

Lanthanide (Ln(3+) )-doped upconversion nanoparticles (UCNPs) as a new generation of multimodal bioprobes have attracted great interest for theranostic purpose. Herein, red emitting nonstoichiometric Na0.52 YbF3.

Organized Molecular Interface-Induced Noncrystallizable Polymer Ultrathin Nanosheets with Ordered Chain Alignment.

The orientation and state of organization of polymer chains play significant roles in determining the final properties and functions of these materials. Unlike most semicrystalline polymers, which have an inherent driving force toward crystallization, the means to control chain packing in noncrystallizable polymers is still restricted and remains a challenge. We report herein a 2D soft template-directed fabrication for ultrathin polyacrylamide nanosheets with a thickness as low as 3.

Conformation of Capping Ligands on Nanoplates: Facet-Edge-Induced Disorder and Self-Assembly-Related Ordering Revealed by Sum Frequency Generation Spectroscopy.

Surface-curvature-amplified conformational disorder in alkyl capping ligands has been observed previously when the nanoparticle radii approach the ligand length. Herein, sum frequency generation studies on oleic-acid-capped nanoplates show that even on faceted surfaces with dimensions tens of times greater than the ligand length a significant proportion of gauche defects exist in the capping layer. The molecular disorder on the nanosized facets is attributed to a facet-edge effect, which is diminished when increasing the facet size or assembling the nanofacets side to side.

Rational design of a thermalresponsive-polymer-switchable FRET system for enhancing the temperature sensitivity of upconversion nanophosphors.

Here we propose a thermoresponsive polymer PNIPAM modulated fluorescence resonance energy transfer (FRET) system to enhance the temperature sensitivity of upconversion nanophosphors (UCNPs). By utilizing red/near-infrared dual emitting NaLuF4:Mn(2+),Ln(3+) (Ln(3+) = Yb(3+), Er(3+), Tm(3+)) UCNPs as the energy donor and Au nanoparticles as the acceptor, the temperature resolution of the UCNPs is significantly increased from 3.1 °C to 0.

Association between IL-6-174G/C polymorphism and risk of multiple sclerosis: a meta-analysis.

Objective: Interleukin-6 (IL-6) is a pleiotropic cytokine and important mediator of many inflammatory processes, which might affect susceptibility to multiple sclerosis (MS). The aim of this study was to assess the effect of IL-6-174G/C polymorphism on the risk of MS using a meta-analysis.

Materials And Methods: The Pubmed, ISI Web of Science, Wanfang, VIP, and China National Knowledge Infrastructure databases were screened and six studies were included in the meta-analysis.