Publications by authors named "Fujimori K"
Background: Osteonecrosis of the femoral head (ONFH) and osteoarthritis (OA) are two common diagnoses for patients undergoing total hip arthroplasty (THA). The early surgical complications in THA for ONFH compared to OA are inconsistently reported. Therefore, this study aimed to evaluate whether THA for ONFH was associated with early postoperative complications in comparison to THA for OA using a large database of Japanese patients.
View Article and Find Full Text PDFFarnesoid X receptor (FXR), a nuclear receptor, is expressed in calvaria and bone marrow stromal cells and plays a role in bone homeostasis. However, the mechanism of FXR-activated osteoblast differentiation remains unclear. In this study, we investigated the regulatory mechanism underlying FXR-activated osteoblast differentiation using bone morphogenetic protein-2 (BMP-2)-induced mouse ST-2 mesenchymal stem cells.
View Article and Find Full Text PDFBackground: Lung cancer surgery is associated with a high incidence of chronic postsurgical pain (CPSP), which necessitates long-term analgesic prescriptions. However, while essential for managing pain, these have shown various adverse effects. Current guidelines recommend using peripheral nerve blocks over epidural anaesthesia for perioperative analgesia in minimally invasive thoracic surgery (MITS).
View Article and Find Full Text PDFPurpose: The association between maternal physique and prevalence of lactational mastitis (LM) in a large study population has not been reported. In this study, we aimed to evaluate the association between pre-pregnancy body mass index (BMI) and LM prevalence.
Methods: We analyzed data collected from participants enrolled in the Japan Environment and Children's Study, a nationwide birth cohort study conducted between 2011 and 2014.
This study aimed to assess long-term changes in pregnancy and birth outcomes after the Great East Japan Earthquake and the accident at the Tokyo Electric Power Company's Fukushima Daiichi Nuclear Power Plant in Fukushima Prefecture. This is the final report on perinatal outcomes of the Prefectural Health Survey, which ended after a 10-year observation period. Questionnaires based on a pregnancy and birth survey conducted by the Radiation Medical Science Center for the Fukushima Health Management Survey were sent to women who had received maternal and child health handbooks from municipal officers in Fukushima Prefecture.
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- Subacute cough is a specific type of cough lasting 3-8 weeks and is primarily caused by cough variant asthma, atopic cough, and sinobronchial syndrome, rather than post-infectious cough as previously believed.
- In a study involving 148 patients, 68.3% developed chronic cough, often stemming from multiple underlying conditions such as cough variant asthma combined with atopic cough.
- The findings highlight the need for careful diagnosis and treatment of multiple causes in patients with subacute cough to prevent progression to chronic cough.
Article Synopsis
- * Researchers analyzed records from around 1100 hospitals over a six-year period, comparing outcomes of patients admitted on weekends versus weekdays after matching for factors like age and comorbidities.
- * Findings indicated no significant increase in complications for weekend admissions; although there was a slight, statistically insignificant trend toward higher mortality, the overall results suggest that weekend hospitalization does not adversely affect recovery in these patients.
Background: The patients taking direct oral anticoagulants (DOACs) are at high risk for developing ischemic stroke and delayed bleeding in upper gastrointestinal endoscopic submucosal dissection (ESD). We aimed to identify the optimal DOAC based on both adverse events in upper gastrointestinal ESD.
Methods: A retrospective population-based cohort study was conducted using the Diagnosis Procedure Combination database in Japan.
Although endoscopic balloon dilation (EBD) is a common therapeutic approach for managing strictures associated with Crohn's disease (CD), the clinical application and complication rates of EBD remain unclear. We collected admission data for patients who underwent EBD using a nationwide database. We compared EBD outcomes between ileal and colonic strictures, CD and ulcerative colitis, and CD and anastomotic strictures arising from cancer-related surgery.
View Article and Find Full Text PDFBreastfeeding, depending on its duration, has been suggested to benefit children's cognitive development. We aimed to examine this issue by using the Japan Environment and Children's Study, a nationwide prospective birth cohort study. We evaluated the relationship between feeding methods and cognitive development in 2- and 4-year-old children.
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- This study investigates the postoperative risks and in-hospital mortality among Japanese patients aged 90 and older with hip fractures, comparing them to those aged 65-89.
- The research utilized a large medical claims database from Japan, analyzing patient records from over 1100 hospitals between April 2016 and March 2022, focusing on various serious complications and mortality rates.
- Findings revealed that super-elderly patients faced significantly higher risks of pneumonia, urinary tract infections, acute renal dysfunction, cognitive issues, and nearly double the in-hospital mortality risk compared to their elderly counterparts, highlighting the need for enhanced perioperative care.
The effect of smoking on hypertensive disorders of pregnancy is a public concern. Recent evidence suggests that the risk of hypertensive disorders of pregnancy is influenced by the presence of uterine fibroids. We explored the association between maternal smoking exposure and the risk of hypertensive disorders of pregnancy in relation to the presence of uterine fibroids using data from Japan's largest birth cohort study.
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- - Thymoma-associated multiorgan autoimmunity (TAMA) involves symptoms like skin issues, liver dysfunction, and enteritis, similar to graft-versus-host disease (GVHD), but occurs without prior stem cell or bone marrow transplants and is linked to thymoma.
- - A 64-year-old woman with myasthenia gravis and thymoma developed skin rashes after a COVID-19 infection, initially suspected to be a drug reaction, but despite treatment adjustments, her condition worsened and led to severe gastrointestinal symptoms.
- - The patient's diagnosis of TAMA was confirmed through skin biopsy showing GVHD-like changes, and her decline included complications from infections, ultimately resulting in her death, with COVID-
Unlabelled: Increased fracture risk due to oral glucocorticoids (GCs) rapidly decreases with GC discontinuation. However, evidence for this is limited. We found that fracture risk decreased rapidly in the first year after GC discontinuation, while hip fracture risk remained higher than reference levels for about two years after GC discontinuation.
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- * It highlights the complexities of performing allogeneic transplants amid active infections, as they typically have poor outcomes.
- * A specific case is presented about a 5-year-old boy with disseminated infection who received granulocyte transfusions from his mother and underwent successful haploidentical stem cell transplantation from his father after immunosuppressive treatment for SAA.
Self-assembled oligonuclear and polynuclear complexes have numerous functionalities and potential applications. Generally, such compounds have been constructed by thermal substitution reactions with bridging ligands. Herein, we report bottom-up and photochemical construction of functional coordination oligomers and polymers by photosubstitution-induced self-assembly.
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- Researchers are exploring porcine organs and human iPSC-derived organoids as potential alternatives for human transplants, but face technical challenges.
- They successfully created human-pig chimeric renal organoids using modified culture systems, leading to continuous kidney development across species.
- This advancement lays groundwork for future clinical applications, making it possible to develop humanized kidneys for transplantation purposes.
Background: The risk of fungal infection in patients with psoriasis receiving biologics is not fully understood in clinical practice.
Objective: To assess the incidence and the risk of fungal infection onset in patients with psoriasis receiving biologics.
Methods: A retrospective cohort study of 592 psoriasis cases treated with biologics at a single center.
Targeted metabolomic analysis of early-trimester serum identifies potential mechanisms for late-onset preeclampsia.
J Matern Fetal Neonatal Med
December 2024
Article Synopsis
- Preeclampsia (PE) is a pregnancy-related high blood pressure issue, and late-onset (Lo)-PE can lead to serious risks for both mothers and children, prompting a study to find biomarkers related to it through maternal serum analysis in the first trimester.
- The research involved 12 Lo-PE patients and 12 healthy pregnant women, using advanced techniques to identify charged metabolites in their serum samples.
- The findings revealed that glucosamine levels were higher and serotonin levels were lower in the Lo-PE group, suggesting these could be early indicators of Lo-PE, and highlighting the importance of diet and mental health in pre-pregnancy care to potentially prevent its occurrence.