Publications by authors named "Fujiko Saavedra"
Article Synopsis
- Genetic and environmental factors contribute to neural tube defects (NTD), notably influenced by the presence of Scavenger Receptor Class B Type 1 (SR-B1) in mouse embryos, where its absence leads to high rates of exencephaly that can be prevented with vitamin E.
- In the study, female mice with SR-B1 were given a high-fat/high-sugar diet to examine its impact on vitamin E levels and oxidative stress in both the mothers and their embryos, along with the incidence of NTD.
- Results showed that the HFHS diet caused metabolic changes and increased NTD rates in embryos, but vitamin E supplementation successfully reduced oxidative stress and improved lipid management in the developing embryos, preventing malformations entirely.
Scope: Quinoa intake exerts hypoglycemic and hypolipidemic effects in animals and humans. Although peptides from quinoa inhibit key enzymes involved in glucose homeostasis in vitro, their in vivo antidiabetic properties have not been investigated.
Methods And Results: This study evaluated the effect of oral administration of a quinoa protein hydrolysate (QH) produced through enzymatic hydrolysis and fractionation by electrodialysis with ultrafiltration membrane (EDUF) (FQH) on the metabolic and pregnancy outcomes of Lepdb/+ pregnant mice, a preclinical model of gestational diabetes mellitus.
Glucocorticoids are frequently used as anti-inflammatory and immunosuppressive agents. However, high doses and/or prolonged use induce undesired secondary effects such as muscular atrophy. Recently, de novo expression of connexin43 and connexin45 hemichannels (Cx43 HCs and Cx45 HCs, respectively) has been proposed to play a critical role in the mechanism underlying myofiber atrophy induced by dexamethasone (Dex: a synthetic glucocorticoid), but their involvement in specific muscle changes promoted by Dex remains poorly understood.
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