[An all-night electroencephalographic study on grand mal epilepsy in childhood. A longitudinal study on the incidence of epileptic discharges with treatment and the comparison between all-night electroencephalography and standard sleep activated electroencephalography].

In order to quantify changes in epileptic discharges during the course of phenobarbital (PB) therapy, 8 children with generalized tonic-clonic seizure (GTC) corresponding to sleep epilepsy as defined by Janz were given PB, and their all-night EEGs were obtained by means of a polygraph with simultaneous measurement of the blood concentration of PB. EEGs were recorded before the treatment commenced and 3 days, 14 days, one month, 6 months, one year, 1.5 and 2 years after the beginning of the treatment.

[8-Hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT)-induced clonic seizure in mice].

In the present study, we examined the clonic seizure immediately preceding head-weaving behaviour elicited by 8-OH-DPAT (40 mg/kg, ip) administration in mice. 8-OH-DPAT, known to be a central 5-HT1A receptor agonist, can induce a clonic seizure. Propranolol (1, 5, 10 mg/kg, ip) and methysergide (10, 20 mg/kg, ip) reduced 8-OH-DPAT (40 mg/kg, ip)-induced head-weaving behaviour and clonic seizure, while ketanserin (125, 250, 500 micrograms/kg, ip) was without effect.

Thoracic disc herniation. Surgical treatment in 23 patients.

The authors' surgical procedure for the treatment of symptomatic thoracic disc herniation has consisted of total discectomy of the involved intervertebral disc, followed by intervertebral body fusion using autogenous iliac bone through an anterior approach. The authors prefer the extrapleural approach to the thoracic vertebrae because of simplified postoperative care with minimum surgical interference with respiratory function. During the past 16 years, 23 patients with symptomatic thoracic disc herniation have been treated by this procedure.

Effect of streptozotocin administration to pregnant mice on serum glucose, glycosylated hemoglobin and weight of organs of the mother mice and their pups.

Administration of streptozotocin (STZ, 200 mg/kg, i.p.) to pregnant mice during either the early or middle stages of pregnancy produced diabetic conditions in the mother mice.

[Proconvulsant effect of morphine on seizures induced by pentylenetetrazol in the mice].

The present study was designed to investigate the proconvulsant effect of morphine (10, 30, 50 mg/kg, sc) in mice on pentylenetetrazol (PTZ)-, picrotoxin-, and bicuculline (BCC)-induced convulsions which are thought to be produced by interactions with GABAergic systems. Morphine increased the severity of seizures induced by the ip (50 mg/kg) and sc (90 mg/kg) routes of administration of PTZ. An administration of morphine caused an increased incidence of multiple seizures following both ip and sc administration of PTZ and prolonged the latency to onset of seizures induced by ip injection of PTZ.

Treatment in fractures of the odontoid process.

Fifty-eight cases of odontoid fractures treated at Keio University Hospital and affiliate hospitals from 1965 through 1985 were reviewed. Six patients under age 7 years (group A), were characterized as having epiphysiolysis. Among 52 patients over 8 years of age (group B), there were two Type I, 31 Type II and 19 Type III fractures.

[Results of surgical treatment of tongue cancer].

Fourty-four patients with squamous cell carcinoma of the tongue have been treated by surgery. Twenty-two out of 44 patients were treated by a glossectomy alone and the remaining 22 by en bloc dissection with a glossectomy and neck dissection. The 5-year cumulative survival rate of these 44 cases was 86.

[Changes in pentobarbital hypnosis and hepatic metabolism in streptozotocin-diabetic mice].

The present study deals with the hypnotic effect of pentobarbital (Pento) in relation to its metabolism in hepatic microsomes in streptozotocin (STZ, 170 mg/kg, i.p.) injected mice.

Central action of cesium chloride in streptozotocin-diabetic mice.

The changes in the pharmacological responses to cesium were examined in streptozotocin(STZ)-induced diabetic mice. An acute administration of cesium chloride (10 mEqCs+/kg IP) to non-diabetic control mice elicited increased salivation and inhibition of respiration followed by death in about half of the animals examined. These effects of cesium were diminished in STZ-diabetic mice.

Effects of nicotinamide and insulin on glycosylated hemoglobin and blood glucose in thyroidectomized streptozotocin-diabetic rats.

The present study deals with the effects of nicotinamide and insulin on glycosylated hemoglobin (HbA1) and blood glucose in thyroidectomized streptozotocin (STZ)-diabetic male rats. Nicotinamide (500 mg/kg body wt., i.

[Changes in glucose metabolism and cardiovascular responses in thyroidectomized streptozotocin treated diabetic rats (author's transl)].

Two weeks after streptozotocin i.v. injection, changes in glucose metabolism, levels of serum and urinary calcium, magnesium and copper, and cardiovascular responses were investigated in thyroidectomized streptozotocin treated diabetic rats.